GPC5

(redirected from glypican-5)

GPC5

A gene on chromosome 13q32 that encodes glypican 5, a cell surface proteoglycan with heparan sulfate that may play a role in the control of cell division and growth. It is primarily expressed in the adult brain.
References in periodicals archive ?
[93]; further candidates since then are NKX2-8, PTCH1, Glypican-5, PARD3, Paraoxonase 1, COMT, AMT, and GLDC genes [16, 17, 206-211].
These include angiopoietin-like 4 (Angptl4), glycoprotein, which is upregulated in rats with steroid sensitive proteinuria [1, 2], interleukin-13 (IL-13), a cytokine that alters podocyte function and is reported to be upregulated in patients with active INS [3, 4], macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counter regulator of the immunosuppressive effects of glucocorticoids [5, 6], glypican-5 gene (GPC5), which encodes a podocyte cell surface proteoglycan whose variants are associated with a podocyte injury and proteinuria [7], and neural nitric oxide synthetase (nNOS) that plays a role in glomerular hyperpermeability [8].
[7] identified an association between variants of glypican-5 (GPC5) gene and acquired NS (focal segmental glomerulosclerosis, proteinuric IgAnephropathy) through a genome wide association study and replication analysis.