glycotoxicity

(glī'kō-tok-sis'i-tē),

Pathologic changes in organs caused by elevated levels of glucose (for example, diabetes).

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References in periodicals archive ?

The clustering of cardiovascular risk factors in DM indicates that the multiple complex metabolic reactions involved in glycotoxicity, lipotoxicity, altered insulin signaling, increased cytokine activity, and interstitial deposition of triacylglycerol may directly or indirectly affect CA function [15-17, 20].

Association and predictive value analysis for resting heart rate and diabetes mellitus on cardiovascular autonomic neuropathy in general population

Overall, the lipoperoxidation and MDA formation might be consequence of dysfunctional glycated proteins, AGEs, and glycooxidative stress glycol-oxidative stress (hyperglycemic glycotoxicity) and consequence of lipotoxicity when lipid is forced into organ cells (e.g., liver, skeletal, and heart muscle and pancreas) significantly impairing functions.

The higher plasma malondialdehyde concentrations are determined by metabolic syndrome-related glucolipotoxicity

In fact, NLRP3 inflammasomes have been proposed to sense and mediate downstream inflammatory events of glycotoxicity and lipotoxicity during the pathogenesis of T2DM [45, 57].

Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation