glycosphingolipid


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glycosphingolipid

 [gli″ko-sfing″o-lip´id]
a fatty acid containing the carbohydrate sugar glucose or galactose.

gly·co·sphin·go·lip·id

(glī'kō-sfing'gō-lip'id),
A ceramide linked to one or more sugars through the terminal OH group; included as glycosphingolipids are cerebrosides, gangliosides, and ceramide oligosaccharides (oligoglycosylceramides). The prefix glyc- may be replaced by gluc-, galact-, lact-, etc.
Synonym(s): ceramide saccharide

gly·co·sphin·go·lip·id

(glī'kō-sfing'gō-lip-id)
A ceramide linked to one or more sugars through the terminal OH group; included as glycosphingolipids are cerebrosides, gangliosides, and ceramide oligosaccharides (oligoglycosylceramides). The prefix glyc- may be replaced by gluc-, galact-, and lact-.
References in periodicals archive ?
Their product line includes a broad range of sphingolipids, glycolipids, glycosphingolipids, fatty acids and esters, sterols, and vitamin E isomers (tocopherols and tocotrienols).
Generalized accumulation of neutral glycosphingolipids with GM2 ganglioside accumulation in the brain.
The role of glycosphingolipid biosynthesis-ganglioseries in CAD disease was also revealed by recent studies.
Takamori, "Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction," FEBS Letters, vol.
Schmitz et al., "Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3," PLoS One, vol.
The globoseries glycosphingolipid SSEA-4 is a marker of bone marrow-derived clonal multipotent stromal cells in vitro and in vivo.
The basic principal of ERT involves the intravenous administration of fully functional enzyme that is taken up by the cells and then delivered to the lysosomes, where the delivered enzyme compensates for the deficient enzyme.In SRT, small molecule drugs are ingested orally, which inhibit the first step in glycosphingolipid biosynthesis, aiming to reduce the rate of glycosphingolipid biosynthesis resulting in reduction of the catabolic effects.
Since the reaction proceeds under mild reaction conditions, this original accelerator, Sn[Cl.sub.2]-AgCl[O.sub.4], was utilized by many researchers in the synthesis of complex glycosides such as Avermectin, (18) Trimeric Lex, (19) Agelagalastatin, (20) [beta]-Mannoside, (21) and glycosphingolipid KRN7000 (Fig.
The anti-asialo-GM1 mouse monoclonal antibody acts against the glycosphingolipid asialo-GM1 antigen, which is expressed on murine NK cells [16].
As shown in Table 2 and Figure 1(a), the significant (P < 0.05) pathways corresponding to downregulated miRNAs were as follows: Fatty acid elongation, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Other types of O-glycan biosynthesis, Thyroid hormone synthesis, Tyrosine metabolism, Mucin type O-glycan biosynthesis, Other glycan degradation, Glycosphingolipid biosynthesis-lacto and neolacto series, Tryptophan metabolism, Gap junction, Proteoglycans in cancer, and signalling pathways regulating pluripotency of stem cells.
CA 19-9 is a glycosphingolipid of the Lewis group that is well known as a tumor-associated antigen.