Harmatz, the trial will investigate leukocyte glycosaminoglycan
(leukoGAGs) levels in three children and skin glycosaminoglycan
(skinGAGs) levels in three adults with MPS VI before and post enzyme replacement therapy (ERT), and in six age-matched control subjects not affected by MPS VI.
Disaccharide analysis of skin glycosaminoglycans
in atrophoderma of Pasini and Pierini.
(NASDAQ : SGMO) reported 16 week reductions in urinary glycosaminoglycans
, a key biomarker of Mucopolysaccharidosis Type II (MPS II) disease pathophysiology, in Cohort 2 of the Phase 1/2 CHAMPIONS Study evaluating SB-913.
Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan
(GAG) content in cartilage.
Formato et al., "Urinary glycosaminoglycans
in patients with systemic lupus erythematosus," Clinical and Experimental Rheumatology, vol.
Glucosamine is a component of glycosaminoglycans
, which is derived from shellfish.
The SimGlycan master database is updated with curated (a) N-glycans derived from Monoclonal antibody (mAb), Bovine Fetuin, Chinese Hamster Ovary (CHO), (b) glycosaminoglycans
derived from Low Molecular Weight Heparin (LMWH), and (c) polysaccharides derived from plants.
Dynamic ECMs form the microenvironment around cells and are composed of collagens, glycoproteins, glycosaminoglycans
(GAGs), and proteoglycans (PGs).
Lysosomal storage disorders (LSDs) (4) are genetic diseases caused by deficiencies of activities of enzymes that degrade substrates including glycolipids, glycosaminoglycans
, and proteins (1).
Proteoglycans are a subset of complex ECM proteins with attached glycosaminoglycans
and have unique properties.
(GAGs) and proteoglycans (PG) in addition to collagen are the main components of extracellular matrix (ECM).
Changes in glycosaminoglycans
and related proteoglycans in intrinsically aged human skin in vivo.