Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to glycosaminoglycan: chondroitin sulfate, proteoglycan, Hyaluronan


any of the carbohydrates containing amino sugars occurring in proteoglycans, e.g., hyaluronic acid or chondroitin sulfate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


General term for a protein-polysaccharide complex obtained from proteoglycans and containing as much as 95% polysaccharide; mucopolysaccharides include the blood group substances. A more modern term is glycosaminoglycan, because all of the known six classes contain major amounts of d-glucosamine and d-galactosamine.
Farlex Partner Medical Dictionary © Farlex 2012


n. Abbr. GAG
Any of a group of unbranched polysaccharides with high molecular weight that contain amino sugars and often are attached to or form complexes with proteins. Also called mucopolysaccharide.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A complex macromolecule considered to be the 'glue' of the cornea. It is responsible for providing the plasticity and structural support needed for successful corneal function. Along with other molecules, it comprises the solid portion of the cornea (,22%, the remainder being water). The distribution and arrangement of glycosaminoglycans are responsible for corneal transparency and thickness.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann

Patient discussion about glycosaminoglycan

Q. Does GAG really help? My mother suffers from osteoarthritis, and after taking a lot of pain-killers someone offered us to try glycosaminoglycans. Does it really help? It’s quite expensive….

A. As far as I know it wasn’t proved in well-controlled trials to benefit the patients over placebo, so if it’s a consideration for you, I’m not sure it justifies the price. However, I’m only a lay-man, so consulting a professional (i.e. a doctor) is better.

More discussions about glycosaminoglycan
This content is provided by iMedix and is subject to iMedix Terms. The Questions and Answers are not endorsed or recommended and are made available by patients, not doctors.
References in periodicals archive ?
(S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells.
[34] Graded mesenchymal Interfacial tissue stem cells engineering osteogenesis Mohan et Glycosaminoglycan Cartilage tissue al.
Piotrowicz, "Antioxidative activity of sulodexide, a glycosaminoglycan, in patients with stable coronary artery disease: a pilot study," Medical Science Monitor, vol.
Formato et al., "Urinary glycosaminoglycan and proteoglycan excretion in normoalbuminuric patients with type 1 diabetes mellitus," Journal of Nephrology, vol.
Glucosamine is a component of glycosaminoglycans, which is derived from shellfish.
Newborn screening for mucopolysaccharidoses: a pilot study of measurement of glycosaminoglycans by tandem mass spectrometry.
(B) Glycosaminoglycan (GAG) content in the cartilage, quantified as [micro]g per mg dry weight.
Smoking has been shown to increase the synthesis of hyaluronic acid by orbital fibroblasts in adipose tissue; furthermore, tissue hypoxia induced by smoking results in the generation of free radicals, which in turn induce the proliferation of orbital fibroblasts and stimulate glycosaminoglycan synthesis and adipogenesis.
van Neck, "Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120," Wound Repair and Regeneration, vol.
[21] reported that there was an decrease in total glycosaminoglycan (HA and DS) content in adult skin relative to fetal skin.
HSA, she continued, "is an analog of endogenous heparan sulfate, a biologically active glycosaminoglycan (GAG) that has been described as the most information-dense biopolymer in nature due to the multiple functions that can perform such as rebalanced dermal matrix health, deep dermal hydration and modulating the activity of key secreted factors and enzymes." Vega told Happi that in addition to its unique anti-aging and pro-skin health properties, HSA is well tolerated even by patients with sensitive skin.
It helps form glycosaminoglycan which produces hyaluronic acid (HA).