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Related to glycosaminoglycan: chondroitin sulfate, proteoglycan, Hyaluronan


any of the carbohydrates containing amino sugars occurring in proteoglycans, e.g., hyaluronic acid or chondroitin sulfate.


General term for a protein-polysaccharide complex obtained from proteoglycans and containing as much as 95% polysaccharide; mucopolysaccharides include the blood group substances. A more modern term is glycosaminoglycan, because all of the known six classes contain major amounts of d-glucosamine and d-galactosamine.


/gly·cos·ami·no·gly·can/ (gli″kōs-ah-me″no-gli´kan) any of a group of high molecular weight linear polysaccharides with various disaccharide repeating units and usually occurring in proteoglycans, including the chondroitin sulfates, dermatan sulfates, heparan sulfate and heparin, keratan sulfates, and hyaluronic acid. Abbreviated GAG.


n. Abbr. GAG
Any of a group of unbranched polysaccharides with high molecular weight that contain amino sugars and often are attached to or form complexes with proteins. Also called mucopolysaccharide.


A complex macromolecule considered to be the 'glue' of the cornea. It is responsible for providing the plasticity and structural support needed for successful corneal function. Along with other molecules, it comprises the solid portion of the cornea (,22%, the remainder being water). The distribution and arrangement of glycosaminoglycans are responsible for corneal transparency and thickness.



any of the carbohydrates containing amino sugars occurring in proteoglycans, e.g. hyaluronic acid or chondroitin sulfate. These substances are secreted in very much greater quantities in the urine of achondroplastic dwarf calves than in other urines. This suggests that the disease is an inherited defect of metabolism similar to the mucopolysaccharidoses of humans. See also glycogenosis.

glycosaminoglycan polysulfate
an antiarthritic compound which affects synovial membrane activity, increasing viscosity of synovial fluid.

Patient discussion about glycosaminoglycan

Q. Does GAG really help? My mother suffers from osteoarthritis, and after taking a lot of pain-killers someone offered us to try glycosaminoglycans. Does it really help? It’s quite expensive….

A. As far as I know it wasn’t proved in well-controlled trials to benefit the patients over placebo, so if it’s a consideration for you, I’m not sure it justifies the price. However, I’m only a lay-man, so consulting a professional (i.e. a doctor) is better.

More discussions about glycosaminoglycan
References in periodicals archive ?
Disaccharide analysis and molecular mass determination to microgram level of single sulfated glycosaminoglycan species in mixtures following agarose-gel electrophoresis.
untreated at-risk patients could be imaged over time to see if, within a few years of the injury, a drug or a lifestyle change is reducing or arresting the loss of glycosaminoglycan from the ligament.
Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (heparan sulfate) by enzyme digestion.
Paul DeAngelis has pioneered these and other intellectual properties related to glycosaminoglycan (GAG) carbohydrate production, including production tools for the important biomaterial hyaluronic acid, HA.
Damage or loss of fibroblasts in the skin leads to reduction in overall production of collagen, elastin and other extracellular matrix ("ECM") components such as hyaluronic acid and glycosaminoglycan which provide structural support and stability to the ECM.
A 50% increase in glycosaminoglycan synthesis was also observed.
Developed by leading medicinal chemists and bioengineers, equitrX consists of a chemically modified glycosaminoglycan that is cross-linked to form a matrix that works with the animal's natural repair system to encourage enhanced production of new healthy tissue.
30, 2014 /PRNewswire/ -- Hyaluronic acid (HA) is a glycosaminoglycan that helps in transportation of nutrients through the body and facilitate water retention in body tissue.
Uracyst is a patented therapeutic used in the treatment of glycosaminoglycan (GAG) deficient cystitis, such as interstitial cystitis ("IC"), radiation induced cystitis and chronically recurring cystitis.
We will be focusing on interstitial cystitis and other presentations of glycosaminoglycan (GAG) deficient cystitis, especially chemical and radiation induced cystitis and chronic cystitis.
0% sodium chondroitin sulfate solution that supplements and replenishes deficiencies in the glycosaminoglycan ("GAG") lining of the bladder wall.
GAG" refers to the glycosaminoglycan lining of the bladder wall, which protects against irritants and toxins in urine and serves as an important barrier against bacterial adherence.