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Related to glycosaminoglycan: chondroitin sulfate, proteoglycan, Hyaluronan


any of the carbohydrates containing amino sugars occurring in proteoglycans, e.g., hyaluronic acid or chondroitin sulfate.


General term for a protein-polysaccharide complex obtained from proteoglycans and containing as much as 95% polysaccharide; mucopolysaccharides include the blood group substances. A more modern term is glycosaminoglycan, because all of the known six classes contain major amounts of d-glucosamine and d-galactosamine.


/gly·cos·ami·no·gly·can/ (gli″kōs-ah-me″no-gli´kan) any of a group of high molecular weight linear polysaccharides with various disaccharide repeating units and usually occurring in proteoglycans, including the chondroitin sulfates, dermatan sulfates, heparan sulfate and heparin, keratan sulfates, and hyaluronic acid. Abbreviated GAG.


n. Abbr. GAG
Any of a group of unbranched polysaccharides with high molecular weight that contain amino sugars and often are attached to or form complexes with proteins. Also called mucopolysaccharide.


A complex macromolecule considered to be the 'glue' of the cornea. It is responsible for providing the plasticity and structural support needed for successful corneal function. Along with other molecules, it comprises the solid portion of the cornea (,22%, the remainder being water). The distribution and arrangement of glycosaminoglycans are responsible for corneal transparency and thickness.



any of the carbohydrates containing amino sugars occurring in proteoglycans, e.g. hyaluronic acid or chondroitin sulfate. These substances are secreted in very much greater quantities in the urine of achondroplastic dwarf calves than in other urines. This suggests that the disease is an inherited defect of metabolism similar to the mucopolysaccharidoses of humans. See also glycogenosis.

glycosaminoglycan polysulfate
an antiarthritic compound which affects synovial membrane activity, increasing viscosity of synovial fluid.

Patient discussion about glycosaminoglycan

Q. Does GAG really help? My mother suffers from osteoarthritis, and after taking a lot of pain-killers someone offered us to try glycosaminoglycans. Does it really help? It’s quite expensive….

A. As far as I know it wasn’t proved in well-controlled trials to benefit the patients over placebo, so if it’s a consideration for you, I’m not sure it justifies the price. However, I’m only a lay-man, so consulting a professional (i.e. a doctor) is better.

More discussions about glycosaminoglycan
References in periodicals archive ?
Improved and simple micro assay for sulfated glycosaminoglycans quantification in biological extracts and its use in skin and muscle tissue studies.
1991) Ovarian glycosaminoglycans potentiate angiogenic activity of epidermal growth factor in mice.
Due to the negative impact of strontium on cartilage glycosaminoglycan levels, we thought it could adversely affect the bladder glycosaminoglycan layer.
It was confirmed by alcian blue staining that all cUCM-MSCs from passage 1 and 5 underwent chondrogenic differentiation, but those in early versus late passage displayed more intense glycosaminoglycan staining.
The effectiveness of vitamin E application apparently lies in deep dermal penetration and the ability to decrease oxygen radicals, which encourages collagen and glycosaminoglycan production.
Ferrarini M, Helfrich DJ, Walker ER, Medsger TA Jr, Whiteside TL: Scleromyxedema serum increases proliferation but not the glycosaminoglycan synthesis of dermal fibroblasts.
When serum was replaced, however, by IGF-1 plus TGF-beta2 an increased glycosaminoglycan production and induction of collagen type II was observed, especially in cells isolated from ear perichondrium.
HA belongs to the glycosaminoglycan (GAG) group, which consists of anionic heteropolysaccharides composed of long, nonramified and repetitive disaccharide units.
It is a natural glycosaminoglycan polysaccharide found in the umbilical cord, vitreous humor and synovial fluid in the human body (3).
uk These tablets will help soothe swollen, sore joints with this natural anti-inflammatory that contains the active ingredient glycosaminoglycan.