Symptoms increase with age due to the progressive glycolipid
accumulation in the vascular system, kidneys and heart leading to kidney failure, heart disease or strokes.
(cerebroside and ganglioside), particularly cerebroside, has been proved to exhibit various physiological activities, including antitumor/cytotoxic (Natori et al., 1994; Jin et al., 1994; Li et al., 1995; Chen et al., 2009), antifungal (Jin et al., 1994), immunomodulatory, cyclooxygenase inhibitory, and antifouling activities (Mansoor et al., 2007).
IgM anti-phenolic glycolipid
I and IgG anti 10-kDp a heat shock protein antibody in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts.
, stearic acid or octadecanoic acid is the main fatty acid chain found in various glycolipid
Brennan, "A novel phenolic glycolipid
from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity," Journal of Bacteriology, vol.
The levels of blood glucose, blood triglyceride, and cholesterol significantly decreased following TSF treatment; these beneficial effects can be achieved via TSF regulating action on the glycolipid
Glycans are a constituent of lipopolysaccharides, glycoproteins, and glycolipids
, and being surface antigens in microorganisms and viruses, they play a key role in the immune recognition of self and foreign antigens.
Natural killer T cells recognize glycolipid
antigens presented by CD1d molecule and may also play an important role in oral tolerance by inducing tolerogenic dendritic cells and regulatory T cells, or by deleting antigen-specific T cells.
Sialic acids widely distributed in nature as terminal sugars in glycoproteins or glycolipids
, impart a net negative charge to cell surface and are reported to be important in cell-to-cell and cell-to-matrix interactions.
(PGL)-I is one of the major components of the cell wall of M.
In this regard, we have identified glycolipid
accumulation and, specifically, lyso-Gb3 accumulation as a driver of uPAR expression in podocytes (Figure 2).
 found that the improvement on glycolipid
metabolism was related with the level of oxidative stress in type 2 diabetic model mice.