GYS1

(redirected from glycogen synthase 1)

GYS1

A gene on chromosome 19q13.3 that encodes glycogen synthase, which adds glucose monomers to growing glycogen chains by forming alpha-1,4-glycoside linkages.

Molecular pathology
Defects of GYS1 cause glycogen storage disease type 0b.
References in periodicals archive ?
Membranes were blocked in 5% nonfat dairy milk in TTBS (10 mM Tris, 100 mM NaCl, and 0.1% Tween-20, pH 7.5) for 1 hour and incubated overnight at 4[degrees]C with primary antibodies (Cell Signaling: Hsp70 1 : 4000, glycogen synthase 1:1000; Abcam: glycogen phosphorylase 1:2000, SERCA2 1 : 1000; Santa Cruz: glucose-6-phosphotase 1 : 200) diluted in TTBS with 2% nonfat dairy milk.
In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1, glucose transporters 1 and 4, and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant.
cinnamon extract; DMEM, Dulbecco's modified Eagle's medium; GLUT, glucose transporter; GSK3B, glycogen synthase kinase 3 beta; GYS1, glycogen synthase 1; IGF, insulin-like growth factor; IGFR, insulin-like growth factor receptor; INS, insulin; INSR, insulin receptor; IRS, insulin receptor substrate; LEP, leptin; LEPR, leptin receptor; PIK3CB, phosphatidylinositol 3-kinase, catalytic, beta; PIK3R1, phosphatidylinositol 3-kinase, regulatory subunit 1; RPL32, ribosomal protein L32; SHC1, Src homology 2 domain-containing transforming protein 1; SOS1, Son of sevenless 1; TTP, tristetraprolin; ZFP36, zinc finger protein 36.

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