glycogen synthase

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gly·co·gen syn·thase

, glycogen starch synthase

a glucosyltransferase catalyzing the incorporation of d-glucose from UDP-d-glucose into 1,4-α-d-glucosyl chains. A deficiency of the liver enzyme may lead to a type of hypoglycemia.

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It's demonstrated that insulin can promote dephosphorylation and activation of glycogen synthase by inactivating the glycogen synthase kinase 3 [32,33].

In ovo feeding of creatine pyruvate alters energy metabolism in muscle of embryos and post-hatch broilers

Silva et al., "Over-expression of muscle glycogen synthase in human diabetic nephropathy," Histochemistry and Cell Biology, vol.

The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice

Greenberg, "Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol," Molecular Microbiology, vol.

Inositols in Insulin Signaling and Glucose Metabolism

Hemmings, "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B," Nature, vol.

Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

Lithium Chloride can Induce Differentiation of Human Immortalized RenVm Cells into Dopaminergic Neurons

Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle.

Molecular Mechanisms of Muscle Glucose Uptake in Response to Resistance Exercise: A Review

Tanuma, "Glycogen synthase kinase-3 [beta]2 has lower phosphorylation activity to tau than glycogen synthase kinase-3 [beta]1," Biological and Pharmaceutical Bulletin, vol.

Root-Securing and Brain-Fortifying Liquid Upregulates Caveolin-1 in Cell Model with Alzheimer's Disease through Inhibiting Tau Phosphorylation

Yoon, "Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation," Proceedings of the National Academy of Sciences, vol.

miR-135b Plays a Neuroprotective Role by Targeting GSK3[beta] in [MPP.sup.+]-Intoxicated SH-SY5Y Cells

Extensive lists of GSK-3 substrates or GSK-3 binding proteins have been reported and include amyloid precursor protein, APC, ATP-citrate lyase, axin, axil, [beta]-catenin, c-jun, Jun B, Jun D, Ci155, C/EBP alpha, CRMP2, CRMP4, CREB, CTP, cyclin D1, dystrophin, eIF2B, glycogen synthase, glucocorticoid receptor, heat shock factor 1, hnRNP, K-casein, KRP, MAB 1B, MAP 2, MAP 2C, MITF, c-Myc, L-Myc, alpha NAC nascent polypeptide-associated complex, NCAM, NDRG1, NDRG2, neurofilament L, neurofilament M, neurofilament H, Notch 1C, p21 CIP1, p53, presenilin, pyruvate DH, PP1 G-subunit, protein phosphatase inhibitor 2, stathmin, synphilin-1, RSK1, and Tau (https://thebiogrid.org/ and http:// www.genecards.org/).

Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases

GSK3[beta]: glycogen synthase kinase 3[beta]; PI3K: phosphatidylinositol 3 kinase; and Cm-EE: Cordyceps militaris ethanolic extract.

Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model

Jope, "The multifaceted roles of glycogen synthase kinase 3[beta] in cellular signaling," Progress in Neurobiology, vol.

Extrinsic Apoptosis Pathway Altered by Glycogen Synthase Kinase-3[beta] Inhibitor Influences the Net Drug Effect on NSC-34 Motor Neuron-Like Cell Survival

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis.

Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease