glycogen phosphorylase


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Related to glycogen phosphorylase: glycogen synthase

phos·phor·y·lase

(fos-fōr'i-lās),
An enzyme cleaving poly(1,4-α-d-glucosyl)n with orthophosphate to form poly(1,4-α-d-glucosyl)n-1 and α-d-glucose 1-phosphate. The active form of the enzyme is a phosphorylated protein.
References in periodicals archive ?
Caption: Figure 4: Hepatic glycogen content (a), glycogen-6-phosphatase (b), glycogen synthase (MGS: muscle glycogen synthase; LGS: liver glycogen synthase) (c), and glycogen phosphorylase (d).
Glycogen phosphorylase isoenzyme BB in diagnosis of myocardial ischaemic injury and infarction.
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen Phosphorylase: synthesis, structure-activity relationships, and X-ray crystallography studies.
(C) Explants from the different experimental conditions were labeled with antibodies against glycogen phosphorylase as a marker of cone photoreceptors.
The synthesis and breakdown of glycogen is controlled by glycogen synthase and glycogen phosphorylase and the regulation of both is characterized by great complexity with many factors [35, 36, 37, 38].
The liver in these patients liberates some glucose, through the action of the debranching enzyme that helps to complete the process of glycogen hydrolysis by allowing the glycogen phosphorylase to continue degrading glycogen (2).
Activity of glycogen phosphorylase (GP) and the content of glycogen in cytosolic fraction and the activities of isocitrate dehydrogenase (ICDH) and succinate dehydrogenase (SDH) in mitochondria liver and skeletal muscle of experimental animals Parameters CON FRU GP (A): Liver 4.11 [+ or -] 0.21 (d) 7.44 [+ or -] 0.30 (a) Skeletal muscle 5.29 [+ or -] 0.23 (d) 8.55 [+ or -] 0.33 (a) Glycogen (B): Liver 54.78 [+ or -] 5.21 (d) 32.14 [+ or -] 3.12 (a) Skeletal muscle 72.21 [+ or -] 4.97 (d) 44.54 [+ or -] 3.68 (a) ICDH (A): Liver 741.2 [+ or -] 28.8 (d) 538.8 [+ or -] 26.
The fish were exposed to lethal (96 h LC50 i.e., 1 ppm) and sublethal (1/10th 96 h LC50 i.e., 0.1 ppm) concentrations of deltamethrin and at the end of the exposure periods, the fish were stunned to death and target organs like gill, liver and muscle were dissected out and glycogen phosphorylase was estimated by method of Sutherland (1955) and glucose-6-phosphatase was estimated by method of Yeung et al,.
"We believe PSN357's ability in pre-clinical studies to inhibit glycogen phosphorylase and reduce blood glucose levels may ultimately offer a competitive therapeutic option for diabetes patients."
Glycogen phosphorylase isoenzyme BB (GPBB) should not be considered a marker of myocardial ischemia; instead, its early release within 2-4 h after the onset of myocardial damage in parallel with myoglobin or heart-type fatty-acid-binding protein is an indicator of irreversible myocardial damage.
Pyridoxal phosphate also acts as a coenzyme for glycogen phosphorylase which releases glucose-1-phosphate from glycogen, an important step in the utilisation of glycogen in muscle.
The glycogen phosphorylase system from the muscle of the blue crab, Callinectes danae.