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guaifenesin (glyceryl guaiacolate)
Pharmacologic class: Propanediol derivative
Therapeutic class: Expectorant
Pregnancy risk category C
Exerts vasoconstrictive action that leads to decreased edema and congestion. Also increases respiratory secretions and reduces mucus viscosity.
Capsules: 200 mg
Oral solution: 100 mg/5 ml, 200 mg/5 ml
Syrup: 100 mg/5 ml
Tablets: 100 mg, 200 mg, 400 mg
Tablets (extended-release): 600 mg
Indications and dosages
➣ Cough due to upper respiratory tract infection
Adults: 200 to 400 mg P.O. q 4 hours (not to exceed 2,400 mg/day), or 600 to 1,200 mg P.O. (extended-release tablets) q 12 hours (not to exceed 2,400 mg/day)
Children ages 6 to 12: 100 to 200 mg P.O. q 4 hours (not to exceed 1,200 mg/day), or 600 mg P.O. (extended-release) q 12 hours (not to exceed 1,200 mg/day)
Children ages 2 to 6: 50 to 100 mg P.O. q 4 hours (not to exceed 600 mg/day)
• Hypersensitivity to drug
• Alcohol intolerance (with some products)
Use cautiously in:
• diabetes mellitus, cough lasting more than 1 week or accompanied by fever, rash, or headache
• patients receiving disulfiram concurrently
• pregnant patients.
• Give with full glass of water.
CNS: headache, dizziness
GI: nausea, vomiting, diarrhea, stomach pain
Skin: rash, urticaria
Drug-diagnostic tests. Urinary 5-hydroxyindoleacetic acid, vanillylmandelic acid: inaccurate results
• Assess cough quality and productivity. Reevaluate treatment if cough persists and is accompanied by fever or headache.
• Tell patient to take with 8 oz of water and to drink plenty of fluids.
• Instruct patient to contact prescriber if cough lasts more than 1 week.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.