GPD1L

(redirected from glycerol-3-phosphate dehydrogenase 1-like)

GPD1L

A gene on chromosome 3p22.3 that encodes a cytoplasmic protein which catalyses the conversion of sn-glycerol 3-phosphate to glycerone phosphate, binding the voltage-gated type V, alpha subunit, of the sodium channel at the plasma membrane.

Molecular pathology
TGPD1L mutations are associated with Brugada syndrome, type 2.
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References in periodicals archive ?
Abbreviations CTGF: Gene encoding for connective tissue growth factor G6PC: Gene encoding for glucose-6-phosphatase GPD1L: Gene glycerol-3-phosphate dehydrogenase 1-like protein PHOX2B: Gene encoding for paired mesoderm homeobox protein 2b SCN5A: Gene encoding for sodium channel protein type 5 subunit alpha, isoform a [Na.sub.v] Sodium ion channel protein, voltage-gated, type V, 1.5: alpha subunit.
Mehdi et al., "Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias," Circulation, vol.
Testeret al, "Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome," Circulation, vol.