Before the introduction of benzodiazepines, anxiety disorders were treated either with the barbiturates or related drugs such as meprobomate and glutethimide
. These agents were highly likely to be abused and led to a great deal of dependence.
Nonbenzodiazepines studied included zopiclone, diphenhydramine, glutethimide
, and promethazine.
Alcohol Adriamycin Amiodarone Chloramphenicol Cis-platinum Dapsone Diphenylhydantoin Disulfiram (Antabuse) (Dilantin) Glutethimide
(Doriden) Gold Hydralazine (Apresoline) Isoniazid (INH) Mega Dose of Vitamin A Mega Dose of Vitamin D Metronidazole (Flagyl) Nitrofurantoin Nitrous Oxide (Furadantin,Macrodantin) (chronic repeated inhalation) Perhexiline (Pexid) Penicillin (Large IV doses only) Pyridoxine (Vitamin B6) Vincristine