If left untreated, coeliac disease can lead to anaemia, osteoporosis, unexplained infertility and neurological conditions such as gluten ataxia
Gluten, a protein found in whole grains, causes a reaction in people with celiac disease, gluten ataxia
(an autoimmune disorder), and non-celiac gluten intolerance.
People diagnosed with the disease must maintain a strict gluten-free diet for the rest of their life if they are to avoid very serious complications such as osteoporosis, infertility and neurological conditions such as gluten ataxia
The autoimmune category includes celiac disease (CD), dermatitis herpetiformis, and gluten ataxia
. Nonceliac gluten sensitivity (NCGS) belongs to the third category, which is the newest and least studied but also the most intriguing.
These include celiac disease, where eating gluten causes the immune system to destroy villi of the small intestine responsible for absorbing nutrients; wheat allergy, which occurs when a person's immune system reacts abnormally to wheat proteins; gluten ataxia
, a rare genetic neurological autoimmune condition; and non-celiac gluten sensitivity, where gluten intake can cause generalised symptoms such as fatigue and gut symptoms.
Health care providers are currently seeing an explosion in the incidence of gluten ataxia
, early dementia, Parkinson's, and aberrant brain function with no clear diagnosis.
Aeschlimann D, Dietary treatment of gluten ataxia
. J Neurol Neurosurg Psychiatry, 2003; 74:1221-24
Gluten sensitivity may present with ataxia known as gluten ataxia
.24% percent of idiopathic cerebellar ataxia is a gluten induced ataxia.
Chattopadhyay et al., "Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia
," The Lancet, vol.
Others include dermatitis herpetiformis, identified by an itchy rash, and the neurological condition gluten ataxia
. Many doctors often mistake this disorder for Parkinson's disease.
This is because the gluten reaction, called gluten ataxia
, targets the cerebellum, the center that controls coordination and complex movements.
Autoantibodies in gluten ataxia
recognize a novel neuronal transglu taminase.