glutathione peroxidase


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Related to glutathione peroxidase: Glutathione reductase

glu·ta·thi·one per·ox·i·dase

[MIM*138320]
an enzyme that catalyzes the reaction of two glutathiones with H2O2, forming glutathione disulfide and two water molecules; a crucial enzyme in hydrogen peroxide detoxification.

glutathione peroxidase

An antioxidant enzyme found in many mammalian cells, including red blood cells. Deficiencies of the enzyme have been linked to an increased risk of acute coronary syndrome.
References in periodicals archive ?
Various oxidative enzymes including copper-zinc superoxide dismutase, manganese superoxide dismutase, glutathione peroxidase, gamma-glutamyl-cysteine synthase, and catalase have an important role to protect the oocyte against the effects of oxidative damage during maturation and early preimplantation embryo development.
During their development to meet superoxide, higher cells design and develop advanced protection enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase) and non-enzymatic systems (glutathione) to avoid more dangerous radicals (12).
Glutathione peroxidase activities in CFH and HL of ark shells exposed to 32[degrees]C showed a biphasic change, with an increase during the initial 12 h followed by a decrease, and then a significant decrease by the end of recovery period.
Erythrocyte lysates were used for determination of catalase, superoxide dismutase, and glutathione peroxidase activity as well as hemoglobin concentrations.
Selenium is essential to the proper functioning of one of the heart's most extensively studied protective mechanisms against oxidative stress--an enzyme called glutathione peroxidase. (84) This enzyme is 100% dependent on having a selenium atom at its core for proper function.
In studies, goji with LBP-5 has been shown to promote healthy skin by significantly increasing blood levels of three important antioxidants: haem oxygenase-1, glutathione peroxidase and superoxide dismutase.
The current studies that have tracked the level of oxidative stress biomarkers in the blood (superoxide dismutase, glutathione peroxidase, glutathione etc.) have highlighted a long-standing oxidative stress in patients with autism--yet, not all the indicators were relevant (13), with mitochondrial dysfunctions being also observed (14) --the roles of these organelles in the oxidative phosphorylation process being well-known.
Six genes, that are known to respond to oxidative stress, were selected for this study: ascorbate peroxidase (APX), catalase (CAT), glutathione peroxidase (GPX), Cu/Zn superoxide dismutase (CSD), an ethylene forming enzyme (EFE) and rubisco activase (RCA).

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