glutathione peroxidase

Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to glutathione peroxidase: Glutathione reductase

glu·ta·thi·one per·ox·i·dase

an enzyme that catalyzes the reaction of two glutathiones with H2O2, forming glutathione disulfide and two water molecules; a crucial enzyme in hydrogen peroxide detoxification.

glutathione peroxidase

An antioxidant enzyme found in many mammalian cells, including red blood cells. Deficiencies of the enzyme have been linked to an increased risk of acute coronary syndrome.


reduced glutathione (GSH), a tripeptide containing glutamic acid, cysteine and glycine, which serves as a reducing agent in many biochemical reactions, being converted to oxidized glutathione (GSSG) in which the cysteine residues of two glutathione molecules are connected by a disulfide bridge. Reduced glutathione is important in protecting erythrocytes from oxidation and hemolysis; deficiency causes sensitivity to oxidant drugs.

glutathione peroxidase
a selenium-containing enzyme whose blood level is a good indicator of the selenium status of the animal; occurs in a plasma form, an enzyme with specificity for phospholipids, and an intracellular form. Called also GPx.
glutathione reductase
a flavin enzyme involved in the defense of the erythrocyte against hemolysis. A partial deficiency occurs relatively frequently but is due to a deficiency of riboflavin; called also GR.
References in periodicals archive ?
Glutathione peroxidase activities in CFH and HL of ark shells exposed to 32[degrees]C showed a biphasic change, with an increase during the initial 12 h followed by a decrease, and then a significant decrease by the end of recovery period.
11 (x) (1) Cooking inactivated catalase (CAT) and decreased the activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly (p<0.
To assess antioxidant defense system activity, the samples (red blood cells) obtained from the control and JIA patients were assayed for catalase (CT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities.
Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress," Molecular Endocrinology, vol.
But it also has many other important functions, including participation in metabolic pathways leading to selenoprotein synthesis, (91,92) and statins have been shown to significantly reduce the synthesis and activity of glutathione peroxidase.
25), which is accompanied by decreasing antioxidant enzyme Glutathione peroxidase and catalase activity in infantile patients with autism, but with a special note, namely the super-expression of SOD activity.
The supernatant obtained were maintained in an ice bath and used for the estimation of total protein, lipid peroxidation, glutathione reductase, reduced glutathione, glutathione peroxidase and superoxide dismutase.
These authors analyzed concentration of selenium and glutathione peroxidase activity in meat (chest and leg) and blood of turkeys slaughtered at 84 days of age, as well as meat qualitative traits.
Increased glutathione peroxidase activities in the embryonic liver were observed in SS and SM treatments between days 9 and 21 of development (P less than 0.
Within the last 10 years, Bionov has focused its R&D strategy on the exploration of the mechanism of action of oral administration with SOD B, and according to Julie Carillon, pre-clinical research manager at Bionov, results "have shown that an SOD B oral supplementation is linked with the induction of endogenous antioxidant enzymes expression--SODs, catalase (CAT), glutathione peroxidase (GPx)--in different animal models.
Therefore, the present study was designed to investigate the effects of PSO on the serum levels of glucose, insulin, malondialdehyde (MDA), glutathione peroxidase, and lipid profile in this model.

Full browser ?