glutathione conjugation

glutathione conjugation,

n a phase II detoxification reaction in the liver; glutathione combines with toxins and converts them into water-soluble mercaptates. Effectively detoxifies acetaminophen and nicotine.
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They demonstrated several metabolic reactions in skin including glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Glutathione conjugation and DNA adduct formation of dibenzo[al]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.
It was found that glutathione conjugation was responsible for herbicide resistance in plants (Del Buono and Ioli 2011).
Glutathione conjugation was a major resistance mechanism for parathion and methyl parathion in diamondback moth (52) and Lygus lineolaris with resistance to malathion had significantly higher (1.
Major issues include the extent of TCE metabolism through cytochrome P450-mediated oxidation and glutathione 5-transferase-mediated glutathione conjugation pathways (Lash et al.
In addition to acting as an important antioxidant for quenching free radicals, glutathione is a substrate responsible for the metabolism of specific drugs and toxins through glutathione conjugation in the liver.
The glutathione S-transferases (GSTs) comprise a supergene family of phase-2 enzymes that catalyze the detoxification of cytotoxic drugs and carcinogens by glutathione conjugation, the process that guards DNA from harm and adduct formation.
Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene.
The formation of the conjugates in small quantities, even if formed their labile characteristics (sensitivity to pH changes), or reversibility of glutathione conjugation could be a few reasons for the existence of comparatively fewer endogenous substrates for GSTs than xenobiotics (Ishikawa et al.
Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process.
Moreover, there are a number of metabolites of potential toxicologic interest, such as chloral, dichloroacetic acid, and those derived from glutathione conjugation, for which reliable pharmacokinetic data is sparse because of analytical difficulties or low concentrations in systemic circulation.

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