2004) fits nicely with the fact that glutathione conjugation
in particular is known to be a major detoxification route for PAs.
Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation.
Moreover, there are a number of metabolites of potential toxicologic interest, such as chloral, dichloroacetic acid, and those derived from glutathione conjugation, for which reliable pharmacokinetic data is sparse because of analytical difficulties or low concentrations in systemic circulation.
Pathways of glutathione conjugation and subsequent metabolism.
Overall, model predictions are consistent with metabolism of TCE occurring predominantly by oxidation compared with glutathione conjugation, and with more TCA produced from oxidation compared with DCA.
Major issues include the extent of TCE metabolism through cytochrome P450-mediated oxidation and glutathione 5-transferase-mediated glutathione conjugation pathways (Lash et al.
Moreover, the data on glutathione conjugation were much more limited, and questions have been raised as to their reliability for making quantitative estimates of the internal dose.
was a major resistance mechanism for parathion and methyl parathion in diamondback moth (52) and Lygus lineolaris with resistance to malathion had significantly higher (1.
3) Glutathione S-transferase (GST) genes, known as a superfamily of phase II metabolic enzymes, catalyze the detoxification of xenobiotics via glutathione conjugation
Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation
of carcinogenic diol epoxide of chrysene.
The formation of the conjugates in small quantities, even if formed their labile characteristics (sensitivity to pH changes), or reversibility of glutathione conjugation
could be a few reasons for the existence of comparatively fewer endogenous substrates for GSTs than xenobiotics (Ishikawa et al.
and conversion to mercapturic acids can occur as an intrahepatic process.