They demonstrated several metabolic reactions in skin including glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation
and DNA adduct formation of dibenzo[al]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.
It was found that glutathione conjugation
was responsible for herbicide resistance in plants (Del Buono and Ioli 2011).
was a major resistance mechanism for parathion and methyl parathion in diamondback moth (52) and Lygus lineolaris with resistance to malathion had significantly higher (1.
Major issues include the extent of TCE metabolism through cytochrome P450-mediated oxidation and glutathione 5-transferase-mediated glutathione conjugation
pathways (Lash et al.
In addition to acting as an important antioxidant for quenching free radicals, glutathione is a substrate responsible for the metabolism of specific drugs and toxins through glutathione conjugation
in the liver.
The glutathione S-transferases (GSTs) comprise a supergene family of phase-2 enzymes that catalyze the detoxification of cytotoxic drugs and carcinogens by glutathione conjugation
, the process that guards DNA from harm and adduct formation.
3) Glutathione S-transferase (GST) genes, known as a superfamily of phase II metabolic enzymes, catalyze the detoxification of xenobiotics via glutathione conjugation
Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation
of carcinogenic diol epoxide of chrysene.
The formation of the conjugates in small quantities, even if formed their labile characteristics (sensitivity to pH changes), or reversibility of glutathione conjugation
could be a few reasons for the existence of comparatively fewer endogenous substrates for GSTs than xenobiotics (Ishikawa et al.
and conversion to mercapturic acids can occur as an intrahepatic process.
Moreover, there are a number of metabolites of potential toxicologic interest, such as chloral, dichloroacetic acid, and those derived from glutathione conjugation
, for which reliable pharmacokinetic data is sparse because of analytical difficulties or low concentrations in systemic circulation.