glutathione S-transferase


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glu·ta·thi·one S-·trans·fer·ase

a class of enzymes that catalyzes the reaction of glutathione with an acceptor molecule (for example, an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway.
Synonym(s): ligandin
References in periodicals archive ?
Summary: Herein, we report the experimental results of the inhibition effects of some phenolic compounds such as 2,4,6-Trihydroxybenzaldehyde, 3,4-Dihydroxy-5-methoxybenzoic acid, Serotonin hydrochloride on [alpha]-amylase, [alpha]-glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and glutathione S-transferase (GST) enzymes.
The research showed the link between paracetamol use and asthma seemed strongest in those who had a particular variant of the glutathione S-transferase (GST) gene, GSTP1.
According to a new research presented at the European Respiratory Society International Congress in 2018, the link between paracetamol use and asthma seemed strongest in those who had a particular variant of the glutathione S-transferase (GST) gene, GSTP1.
The Glutathione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance.
[10] Glutathione S-transferase (GST) was measured by spectrophotometric assay according to the method of Mozer et al.
Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant Chinese hamster ovary cells.
Vermeulen, "Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity," Critical Reviews in Toxicology, vol.
The homogenates were used for the assays of lipid peroxidation and PMS for glutathione, glutathione peroxidase, glutathione reductase, catalase, glutathione S-transferase, and superoxide dismutase [15].
Identification of an N-capping box that affects the alpha 6-helix propensity in glutathione S-transferase superfamily proteins: a role for an invariant aspartic residue.
Another mechanism is the production of FosA, a glutathione S-transferase that inactivates fosfomycin by addition of a glutathione residue.
Background: Several studies concerning the association between glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and male infertility risk have reported controversial findings.
ROS and xenobiotics are neutralized by GSH via glutathione S-transferase (GST); this enzyme converts these compounds into water-soluble compounds that can be easily eliminated (4,5).