glutamine synthetase

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Related to glutamine synthetase: glutaminase, glutamate synthase

glu·ta·mine syn·the·tase

an enzyme that catalyzes the reaction of l-glutamate, ammonia, and ATP to glutamine, ADP, and orthophosphate; one of the few known mammalian enzymes that uses ammonium ion as a substrate under physiologic conditions.


An intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.

Molecular pathology
GLUL mutations are associated with congenital glutamine deficiency.


Gln; an amide of glutamic acid, an amino acid occurring in proteins; it is an important carrier of ammonia to the kidney where it is released by glutaminase.

glutamine synthetase
enzyme catalyzing the synthesis of the amino acid, glutamine from glutamate ammonia and ATP. Major means of detoxifying ammonia from amino acid catabolism in peripheral tissues and then transporting the ammonia as the amido-N in glutamine to the liver of kidney.
References in periodicals archive ?
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma.
The aim of the research is to study the activity of glutamine synthetase enzyme, the formation of leaf surface of planting, and the yield capacity of spring wheat grain depending on the time periods and doses of nitrogen fertilizers in conditions of the eastern part of the Volga-Vyatka region.
In the CaCl2 treatment, the glutamine synthetase (GS) activity was significantly higher than of control at each temperature and no effect of TFP treatment during the entire experiment was observed (Fig.
Effects of catalpol on lactate debydrogenase (LDH), glutamine synthetase (GS) and creatine kinase (CK) in the spleen of seneseent miee induced by d-galactose Groups LDH (U/mg GS (U/mg CK (U/mg protein) protein) protein) Control group 613.
Fine structural localization of glutamine synthetase in astrocytes of rat brain.
neutralization of said glutamine synthetase inhibitor.
2] on glutamine synthetase activity in cell-free extracts of YFE leaves of P.
With increase of nitrogen rate, significant increase in the activities of nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase was noted, which caused an increase in protein and amino acid contents in all the genotypes.
In our laboratory, we find that reticulin, glypican-3 (Gly3), and glutamine synthetase (GS) are the most reliable stains and the easiest to interpret.
Nitrate reductase and glutamine synthetase activity and growth in Ulva lactuca in Waquoit Bay: a time sequence of responses to differences in nitrogen supply (p.
The only way to eliminate any ammonia that has reached the brain cells is through a reaction mediated by an enzyme called glutamine synthetase, which is found in the astrocytes.
Basta herbicide is a sterilant herbicide and the actual site of its target is glutamine synthetase.

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