glutamic acid decarboxylase autoantibodies

glutamic acid decarboxylase autoantibodies

Autoantibodies that can be predictors DIABETES and that also occur in the STIFF PERSON SYNDROME. Glutamic acid decarboxylase is the enzyme that catalyzes the decarboxylation of the amino acid glutamic acid, the product being 4-aminobutyrate. The immunological link between diabetes and the STIFF PERSON SYNDROME remains obscure.
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Abbreviations DKA: Diabetic ketoacidosis ICU: Intensive care unit PD-1: Antiprogrammed death 1 receptor PD-1L: Programmed death ligand GADA: Glutamic acid decarboxylase autoantibodies IAA: Insulin autoantibodies IA-2A: Islet antigen 2 autoantibodies ICA: Islet cell antibodies ZnT8A: Zinc transporter 8 autoantibodies.
[18] Undetectable GADA, IA-2, IAA This study Undetectable No DKA: diabetic ketoacidosis; F: female; NSCLC: nonsmall cell lung cancer; SCLC: small cell lung cancer; RCC: renal cell carcinoma; GADA: glutamic acid decarboxylase autoantibodies; IAA: insulin autoantibodies; ICA: islet cell antibodies; NA: not available; IA-2: islet 2 autoantibody.
Encephalitis associated with glutamic acid decarboxylase autoantibodies in a child: a treatable condition?
Durif, "Intravenous immunoglobulin and rituximab for cerebellar ataxia with glutamic acid decarboxylase autoantibodies," Cerebellum, vol.
Although questioned repeatedly [4], current criteria for the diagnosis of LADA remain age at the onset, the presence of positive diabetes-associated autoantibodies--islet-cell cytoplasm autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GAD65A), insulinoma-associated-2 antibodies--tyrosine phosphatase associated (IA-2A), zinc transporter 8 autoantibodies (ZnT8A); and satisfying glycemic control without insulin treatment for at least 6 months after diagnosis [5-8].
McMenamin et al., "Neuronal surface and glutamic acid decarboxylase autoantibodies in nonparaneoplastic stiff person syndrome," JAMA Neurology, vol.
Among type 1 diabetics, 27(67.5%) tested positive for glutamic acid decarboxylase autoantibodies compared to 15(25%) in type 2 diabetics, 6(15%) among relatives of type 1, 7(11.7%) among relatives of type 2 diabetic patients, and none among controls.

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