Klockgether, "Cerebellar ataxia with glutamic acid decarboxylase
autoantibodies," Neurology, vol.
Verlohren et al., "Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase
discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA)," Diabetologia, vol.
Glutamic acid decarboxylase
in Parkinson's disease and epilepsy.
In addition, the critical step in GABA biosynthesis is the decarboxylation of glutamate by glutamic acid decarboxylase
Harmonization of glutamic acid decarboxylase
and islet antigen-2 autoantibody assays for National Institute of Diabetes and Digestive and Kidney Diseases consortia.
Islet cell antibodies and glutamic acid decarboxylase
antibodies but not the clinical phenotype help to identify type 1V2 diabetes in patients presenting with type 2 diabetes.
Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase
in diagnosis and prediction of insulin dependency.
A The company received the two year grant from the United States Department of Veterans Affairs (VA).A Fund will be used by the company for the advancement of NTDDS with Glutamic Acid Decarboxylase
(GAD) through preclinical efficacy, toxicology and biodistribution studies, manufacturing and filing of an Investigational New Drug (IND) application with the Food and Drug Administration (FDA).
Latent autoimmune diabetes, which is believed to signal slowly progressive autoimmune [beta]-cell destruction, is a form of type 1 disease characterized by adult on-set; circulating islet cell antibodies and glutamic acid decarboxylase
antibodies; and no initial need for insulin therapy.
The appearance of autoantibodies to (3-cell antigens, such as insulin, the 65-kDa isoform of glutamic acid decarboxylase
(GAD65)', and protein tyrosine phosphatase-like molecule (IA-2), into the peripheral circulation predicts clinical disease, and the presence of multiple autoantibodies and IA-2 autoantibodies JA2-As) indicates high probability that the disease will appear soon (1, 2).
In 41 infants who had a parent or sibling with type 1 diabetes, significant increases in rotavirus antibodies coincided with the first appearance of insulin autoantibodies in 19 of 23, with antibodies to glutamic acid decarboxylase
(GAD) in 14 of 20, and with IA-2 antibodies in 14 of 21 at-risk infants.
The major autoantibodies in DM1 are against islet cells, insulin, a protein tyrosine phosphatase-like protein (IA-2), and the 65-kDa isoform of glutamic acid decarboxylase