glutamatergic


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glutamatergic

(glū'tă-mă-tĕr'jik),
Pertaining to the action of glutamate or to neural or metabolic pathways in which it functions as a transmitter.
[glutamate + G. ergon, work]
References in periodicals archive ?
(36) Modafinil also blocked relapse to morphine CPP by a possible involvement of the glutamatergic system in its action.
(1994) Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro.
It acts as a highly selective, noncompetitive antagonist on AMPA receptors, thereby reducing glutamatergic transmission.
And we found that the upregulated DEGs are mainly implicated with cell cycle, ECM-receptor interaction, and p53 signaling pathway, while the downregulated genes were enriched in retrograde endocannabinoid signaling, glutamatergic synapse, morphine addiction, GABAergic synapse, and calcium signaling pathway.
Studies using neuronal cultures and acute slices from different brain areas and in different species support a selective role for neuroligin-1 (NL1) in the function of glutamatergic synapses [35].
Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory.
Continuous studies have shown that the mechanism of PD involves many nondopaminergic mechanisms including adenosine receptors (ARs), glutamatergic, adrenergic, serotoninergic, histaminic, and iron chelator pathways.[sup][3],[4],[5],[6] Targeting nondopaminergic systems could prove an effective alternative approach to enhance efficacy and improve motor complications in PD.[sup][7] The aim of this article was to review currently available nondopaminergic therapeutic options, including clinically available options and those in clinical trials, for motor symptoms and motor complications in PD.
For intervention, a treatment with a Cholinesterase inhibitor as well as a glutamatergic agent (NMDA receptor antagonist), including Aricept and Namenda, can be used for this form of Alzheimer's disease.
Comment: Hyperactivity of glutamatergic neurotransmission has been implicated in the pathogenesis of OCD.
In one dish, they grew cells called glutamatergic neurons, because they secrete the chemical glutamate, responsible for sending excitatory messages in the brain.
Endocannabinoids are synthesized as a result of the activation of the post-synaptic cell, particularly the activation of muscarinic receptors and metabotropic glutamatergic receptors.
These include glutamatergic, GABAergic, opioid, and anti-inflammatory drugs.

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