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Any of a family of enzymes that transfer d-glucuronate to the acceptor named, forming glucuronosides, for example, UDPglucuronate-bilirubin glucuronosyltransferase.
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References in periodicals archive ?
Posaconazole, in contrast to itraconazole and voriconazole, is metabolized predominantly via uridine diphosphate glucuronosyltransferase (UGT) pathways instead of by the CYP450 system (28).
[3] Human genes: UGT2B17, UDP glucuronosyltransferase family 2 member B17; F9, coagulation factor IX; SRY sex determining region Y; BCR, BCR, RhoGEF and GTPase activating protein; ABL, ABL proto-oncogene 1, non-receptor tyrosine kinase; FLT3, fms related tyrosine kinase 3; NPM1, nucleophosmin 1.
UDPGT: uridine diphosphate glucuronosyltransferase; EPHX: epoxide hydrolase; GSH: glutathione.
found that due to a lack in the enzyme uridine-diphosphate glucuronosyltransferase (UGT1A) and exhibiting an elevation of plasma bilirubin concentration, the mice reduced streptozotocin-induced pancreatic [beta]-cell dysfunction by weakening oxidative stress [24].
Nadanaka, Beta-1,3-glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3), Handbook of Glycosyltransferases and Related Genes, Springer, Japan, 2014.
This case stresses the role of a uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism in the magnitude of observed toxicity.
There were 53 DEGs enriched in this pathway, and these included the up-regulated DEGs encoding UDP glucuronosyltransferase (UGT) and the down-regulated DEGs encoding 17[beta]-hydroxysteroid dehydrogenases, 3-oxo-5-beta-steroid 4-dehydrogenase, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, and estronesulfotransferase.
Recent studies have investigated that after tea consumption, catechins are metabolized and transformed as sulfated, methylated, or glucuronidated derivatives by enzymes such as sulfotranferase, catechol-O-methyltransferase and glucuronosyltransferase respectively [16] and it has been hypothesized that breakdown of flavonoids into smaller phenolic acids takes place within the colon from bacterial degradation, absorption occurs through the small intestine.
The list includes NAD(P)H: quinone oxidoreductase 1 (Nqol), uracil diphosphate- (UDP-) glucuronosyltransferase 1A6 ( Ugt1a6), UDP-glucuronosyltransferase (UGT) 1A9 ( Ugt1a9), glutathione S-transferase (GST) A1 (Gsta1), and a number of other isoforms of UGT and GST [16].
In humans, UGT1A1 is the unique glucuronosyltransferase enzyme catalyzing the conversion of bilirubin into highly hydrophilic and easily excretable glucuronide derivatives [7], and MRP2 ensures the export of these derivatives into the bile (Figure 5) [5].
(b) 2D6, (c) and 2C9, (d) and uridine 5'-diphosphate glucuronosyltransferase (e) are increased during pregnancy, whereas the activities of CYP1A2 (f) and 2C19 (g) are decreased.