glucuronic acid


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glucuronic acid

 [gloo″ku-ron´ik]
a uronic acid formed by oxidation of C-6 of glucose to a carboxy group; it occurs in proteoglycans (mucopolysaccharides), and is important in the conjugation of xenobiotics; it is conjugated to many poisons and drugs by the liver, forming glucuronides, which markedly decreases their toxicity and enhances their excretion by the liver, intestine, and kidney.

glu·cu·ron·ic ac·id

(glū'kū-ron'ik as'id),
The uronic acid of glucose in which C-6 is oxidized to a carboxyl group; the d-isomer detoxicates or inactivates various substances (for example, benzoic acid, phenol, camphor, and the female sex hormones) undergoing conjugation with such substances in the liver, the glucuronides so formed being excreted in the urine.

glu·cu·ron·ic ac·id

(glū'kyūr-on'ik as'id)
The uronic acid of glucose in which C-6 is oxidized to a carboxyl group; the d-isomer detoxicates or inactivates various substances (e.g., benzoic acid, phenol, camphor, and the female sex hormones), the glucuronides so formed being excreted in the urine.

glucuronic acid

A substance formed from glucose that combines with many body waste products to form glycosides that are excreted in the urine.
References in periodicals archive ?
B-- Simple medium R = Rhamnose; G = Glucose; M = Mannose; A = Glucuronic acid; 8, 24, 48, 96 and 120 = Culture time in hours relative to each sample.
glucuronic acid conjugate; J Chromatogr B 833:245; 2006.
Heme is converted to unconjugated bilirubin, which is secreted into the plasma, bound to albumin, and transported to the liver, where it is conjugated to glucuronic acid and excreted in bile.
In liver, Glucuronyl transferase conjugates bilirubin with two molecules of glucuronic acid, forming bilirubin diglucuronide.
This enzyme attaches glucuronic acid to testosterone, making it more likely to be excreted through urine.
After the bilirubin has entered the liver cells, the cells conjugate (attaching other chemicals, primarily glucuronic acid) to the bilirubin, and then secrete the bilirubin/glucuronic acid complex into bile.
The biopolymer is a glycosaminoglycan and is comprised of repeating disaccharide units that contain a glucuronic acid and N-acetyglucosamine units.
Hyaluronic acid contains glucuronic acid (GlcUA), a representative biogenic carboxylic, and GlcNAc, a representative biogenic amine.
In nature, the enzyme cleaves glucuronic acid from hemicellulose and, in so doing, helps disassemble plant cell walls.
Desvenlafaxine-glucuronide is the final metabolite of conjugation reaction with glucuronic acid. N-desvenlafaxine-glucuronide is an end product of a 2-step metabolic reaction that starts with oxidation by CYP 3A4 to produce N-desvenlafaxine, which is conjugated with glucuronic acid to create N-desvenlafaxine-glucuronide.
This compound, which is formed in the liver by linking ethanol with glucuronic acid, remains detectable in serum, plasma, and hair for days after alcohol consumption.
This highly branched polysaccharide is a complex mixture of Ca, Mg and K salts of arabic acid that contains galactose, rhamnose, glucuronic acid, 4-O-methyl glucuronic acid and arabinose residues (16).