glucuronic acid


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glucuronic acid

 [gloo″ku-ron´ik]
a uronic acid formed by oxidation of C-6 of glucose to a carboxy group; it occurs in proteoglycans (mucopolysaccharides), and is important in the conjugation of xenobiotics; it is conjugated to many poisons and drugs by the liver, forming glucuronides, which markedly decreases their toxicity and enhances their excretion by the liver, intestine, and kidney.

glu·cu·ron·ic ac·id

(glū'kū-ron'ik as'id),
The uronic acid of glucose in which C-6 is oxidized to a carboxyl group; the d-isomer detoxicates or inactivates various substances (for example, benzoic acid, phenol, camphor, and the female sex hormones) undergoing conjugation with such substances in the liver, the glucuronides so formed being excreted in the urine.

glucuronic acid

/glu·cu·ron·ic ac·id/ (gloo-ku-ron´ik) the uronic acid derived from glucose; it is a constituent of several glycosaminoglycans and also forms conjugates (glucuronides) with drugs and toxins in their biotransformation.

glu·cu·ron·ic ac·id

(glū'kyūr-on'ik as'id)
The uronic acid of glucose in which C-6 is oxidized to a carboxyl group; the d-isomer detoxicates or inactivates various substances (e.g., benzoic acid, phenol, camphor, and the female sex hormones), the glucuronides so formed being excreted in the urine.

glucuronic acid

A substance formed from glucose that combines with many body waste products to form glycosides that are excreted in the urine.

glucuronic acid

a uronic acid formed by oxidation of C-6 of glucose to a carboxy group; it occurs in proteoglycans (mucopolysaccharides), and is conjugated in the liver with many natural and foreign compounds or their metabolites, forming glucuronides, which are excreted in the urine.

glucuronic acid pathway
References in periodicals archive ?
There were no significant differences between the assay's response to glucose and its response to glucuronic acid or starch (Student's t test, P = 0.
Production of glucuronic acid in the urine was compared between populations using nested analysis of covariance (ANCOVA) with resin intake as a covariate.
method using D-galactose as standard; (c)-- Dosage by Dische' method using glucuronic acid as standard; (d)--Dosage by Bradford' method using bovine serum albumin (-not detected); (e)-- sulfate, (f)--carbon, (g)--hydrogen and (h)--nitrogen were determined by elemental microanalysis using a CHN equipment Perkin Elmer model 2400 (MACIEL et al.
These analyses revealed that the new glycosyl bond between the N-acetylglucosamine transferred from the donor and glucuronic acid at the reducing terminus of the acceptor was the same as the original bond i.
Valproate is extensively conjugated to glucuronic acid, and more than half of an ingested dose is excreted in the urine as the glucuronide, along with smaller amounts of hydroxylated valproate metabolites and their glucuronide conjugates.
We assess the metabolic costs of detoxifying ingested PSMs by measuring the nutrient drain associated with excretion of glucuronic acid and ornithine, two major substrates used in phase II conjugation reactions in birds (Sykes 1971).
Hydroxyproline, glucuronic acid lactone and oligonucleotide primer sequences were purchased from Sigma Aldrich (Bangalore, India).
However, one polysaccharide isolated from burley tobacco was reported to be composed of galactose, arabinose, glucuronic acid and r hamnose [15].
The supershort hyaluronic acid molecule has two repeats of glucuronic acid and glucosamine and a molecular weight of around 800.