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glucuronic acid

a uronic acid formed by oxidation of C-6 of glucose to a carboxy group; it occurs in proteoglycans (mucopolysaccharides), and is important in the conjugation of xenobiotics; it is conjugated to many poisons and drugs by the liver, forming glucuronides, which markedly decreases their toxicity and enhances their excretion by the liver, intestine, and kidney.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


A salt or ester of glucuronic acid.
Farlex Partner Medical Dictionary © Farlex 2012


A salt or ester of glucuronic acid.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Lovria et al., "Superparamagnetic [Fe.sub.3][O.sub.4] Nanoparticles: synthesis by thermal decomposition of Iron(III) glucuronate and application in magnetic resonance imaging," ACS Applied Materials & Interfaces, vol.
In body fluids, [E.sub.3] exists in conjugated forms with sulfate or glucuronate, with only a small fraction of the total [E.sub.3] present as unconjugated [E.sub.3] (u[E.sub.3]) (5).
Other pathways are considered modestly affected by feeding CLA (5.78 [+ or -] 0.5 SD (8.4)) including riboflavin metabolism, fatty acid elongation in mitochondria, ErbB signaling, and pentose and glucuronate interconversions, which were activated (Figure 2).
* Trimetrexate glucuronate (with Leucovorin)(Neutrexin, TMTX), U.S.
The mammalian lignans, enterodiol and enterolactone, can be excreted directly in the feces, or after being absorbed in the gut, they enter the enterohepatic circulation where they are conjugated with glucuronate, and then excreted in urine and bile [10,11].
NuTrexin (trimetrexate glucuronate) was developed by U.S.
MRP1 demonstrated a substrate preference for negatively charged substrates, such as glutathione, glucuronate, and sulfate conjugates, suggesting its role in maintaining cell redox state.
Glutathione, glucuronate, and sulphate-conjugated organic anions are MRP1 substrates [14,15].