Thus, the loss of glucose reduces the potential glucotoxicity
and the risk of beta cell failure (24).
This is called the "thrifty phenotype hypothesis."  And the third is, unfavourable metabolic environment, especially increased glucose levels which may induce glucotoxicity
and a persistent increase in NEFA levels that may induce lipotoxicity.
Marked recovery from glucotoxicity
of?-cell function after medical nutrition therapy without pharmacotherapy in type 2 diabetic outpatients with extreme hyperglycemia: a pilot retrospective study.
Stromal cell derived factor-1 alpha protects stem cell derived insulin-producing cells from glucotoxicity
under high glucose conditions in-vitro and ameliorates drug induced diabetes in rats.
Starting insulin therapy early on in the disease may actually restore beta-cell function and reduce glucotoxicity
. (24) In elderly patients with uncontrolled diabetes, early treatment with basal insulin results in better glycemic control and less hypoglycemia than continuing to titrate oral agents.
Cells are also damaged by hyperglycaemia, either directly, or by oxidative stress (glucotoxicity
Some of our data showed that 15 mM glucose had negatively affected the cell proliferation and GHRH-R expression; we thought this might be due to glucotoxicity
Two to five weeks of CSII can reduce glucotoxicity
, ameliorate insulin resistance, and promote recovery of [beta]-cell function in subjects with newly diagnosed type 2 diabetes [13,14].
In those with impaired glucose regulation, the damage of [beta]-cell function became more evident, and at the same time more mechanisms such as glucotoxicity
, lipotoxicity , inflammation , and oxidative stress  could emerge and together contribute to [beta]-cell dysfunction, making the effect of SVR on [beta]-cell negligible.
Ris et al., "Glucose-induced j cell production of IL-1[beta] contributes to glucotoxicity
in human pancreatic islets," The Journal of Clinical Investigation, vol.
and metabolic imbalance caused by poor glycemic control lead to more severe complication at earlier ages, implying a need for a novel and practicable criterion for early diagnosis and monitoring of complications.
T2DM is associated with insulin secretion disorder of [beta] cells and insulin resistance, which is defined as the deterioration of normal biological response to exogenous and endogenous insulin, and many resultants can be regarded, such as genetic factors, cellular receptor mechanism, low birth weight, obesity, lifestyle, glucotoxicity
, lipotoxicity, islet amyloid, adiposyte products, and inflammation (6).