The weekly dual glucose-dependent insulinotropic polypeptide
, or GIP, and GLP-1 receptor agonist integrates the action of both incretins into a single novel molecule, aiming to build upon the clinical benefits seen with a selective GLP-1 RA.
It combines glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide
(GIP), and glucagon which are all growth factors.
Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide
and glucagon-like peptide-1.
McIntosh, "Resistin is a key mediator of glucose-dependent insulinotropic polypeptide
(GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes," Journal of Biological Chemistry, vol.
Hartmann et al., "Glucose-dependent insulinotropic polypeptide
(GIP) receptor antagonists as anti-diabetic agents," Peptides, vol.
It has been reported that GLP-1 can control bone resorption by interacting with GLP-2 and glucose-dependent insulinotropic polypeptide
Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide
, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects.
Shearer, "Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide
response in rats," Applied Physiology, Nutrition, and Metabolism, vol.
Pederson, "Degradation of glucose-dependent insulinotropic polypeptide
and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV"' Endocrinology, vol.
A DPP-4 inhibitor enhances the insulin secretion based on the plasma glucose levels, and it controls the levels by selectively inhibiting DPP-4 activity that inactivates two hormones, the incretin hormones (gastrointestinal hormones that promote insulin secretion) that play important roles in adjusting blood glucose, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide
Among these, enteroendocrine cells include more than 10 different cell types producing distinct hormones or hormone-like substances such as serotonin, secretin, glucose-dependent insulinotropic polypeptide
, glucagon-like peptide, pancreatic polypeptide, etc.
Global Markets Direct's, 'Gastric Inhibitory Polypeptide Receptor (GIP-R or Glucose-Dependent Insulinotropic Polypeptide
Receptor or GIPR) - Pipeline Review, H1 2016', provides in depth analysis on Gastric Inhibitory Polypeptide Receptor (GIP-R or Glucose-Dependent Insulinotropic Polypeptide
Receptor or GIPR) targeted pipeline therapeutics.