glucose-6-phosphate dehydrogenase

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Related to glucose-6-phosphate dehydrogenase: pentose phosphate pathway, glucose-6-phosphate dehydrogenase test


an enzyme that mobilizes the hydrogen of a substrate so that it can pass to a hydrogen acceptor.
glucose-6-phosphate dehydrogenase an enzyme necessary for the oxidation of glucose-6-phosphate, an intermediate in carbohydrate metabolism. Hereditary deficiency of this enzyme in the erythrocytes is associated with a tendency toward hemolysis upon ingestion of certain antimalarial agents and sulfonamide drugs and fava beans (see favism.
lactate dehydrogenase (LDH) an enzyme that catalyzes the interconversion of lactate and pyruvate. It is widespread in tissues and is particularly abundant in kidney, skeletal muscle, liver, and myocardium. It appears in elevated concentrations when these tissues are injured.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

glu·cose-6-phos·phate de·hy·dro·gen·ase

(glū'kōs fos'fāt dē'hī-droj'en-ās),
An NADP+-dependent enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-δ-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents respiratory burst in neutrophils.
Farlex Partner Medical Dictionary © Farlex 2012

glucose-6-phosphate dehydrogenase (G-6-PD)

an important enzyme in the PENTOSE PHOSPHATE PATHWAY for carbohydrate metabolism, catalysing the oxidation of glucose 6-phosphate in the presence of NADP coenzyme, giving 6-phosphogluconolactone and NADPH. G-6-PD of blood erythrocytes is of particular interest because a decrease in its activity can lead to the condition called FAVISM.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Measurement Patient value Direct Coombs test Negative Total bilirubin 4.1 mg/dL (RI, <20 mg/dL) Conjugated bilirubin 0.4 mg/dL (RI, <0.4 mg/dL) G6PDH first sample ND mU/[10.sup.9] erythrocytes G6PDH second sample 2 mU/[10.sup.9] erythrocytes (RI, 138-171 (at age 10 d) mU/[10.sup.9] erythrocytes) RI, reference interval; G6PDH, glucose-6-phosphate dehydrogenase (Ref.
Tichy, "Review and drug therapy implications of glucose-6-phosphate dehydrogenase deficiency," American Journal of Health-System Pharmacy, vol.
Effect of experimental diabetes on the activities of hexokinase, glucose-6-phosphate dehydrogenase and catecholamines in rat erythrocytes of different ages.
Capoluongo, "Glucose-6-phosphate dehydrogenase laboratory assay: how, when, and why?," IUBMB Life, vol.
Stanton, "Glucose-6-phosphate dehydrogenase, NADPH, and cell survival," IUBMB Life, vol.
A plastidic glucose-6-phosphate dehydrogenase is responsible for hypersensitive response cell death and reactive oxygen species production.
Genetics of castes and tribes of India: glucose-6-phosphate dehydrogenase deficiency and abnormal haemoglobins (HbS and HbE).
Prevalence of glucose-6-phosphate dehydrogenase deficiency in US Army personnel.
In particular, they generated transgenic mice with an increased expression throughout their bodies of one of the most important enzymes for the production of NADPH, namely, glucose-6-phosphate dehydrogenase (or G6PD).
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked genetic disorder, is a common human enzymopathy affecting over 400 million individuals worldwide [1].
Background: Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme essential for basic cellular functions, including protection of red cell proteins from oxidative damage.

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