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Related to glucose-6-phosphatase: glucose-6-phosphate dehydrogenase


(glū'kōs fos'fă-tās),
A liver enzyme catalyzing the hydrolysis of d-glucose 6-phosphate to d-glucose and orthophosphate; this enzyme is deficient in glycogen storage disease Ia.


/glu·cose-6-phos·pha·tase/ (fos´fah-tās″) an enzyme that catalyzes the hydrolytic dephosphorylation of glucose 6-phosphate, the principal route for hepatic gluconeogenesis; deficiency causes glycogen storage disease, type I.

glucose, d-glucose

a simple sugar, a monosaccharide in certain foodstuffs, especially fruit, and in normal blood; the major source of energy for many living organisms. See also dextrose.
Glucose, whose molecular formula is C6H12O6, is the end product of carbohydrate digestion; other monosaccharides (fructose and galactose) are largely converted into glucose. Glucose is the only monosaccharide present in significant amounts in the body fluids. The oxidation of glucose produces energy for the body cells; the rate of metabolism is controlled by a number of hormones the most important of which are insulin and glucagon. Glucose that is not needed for energy is stored in the form of glycogen as a source of potential energy, readily available when needed. Most of the glycogen is stored in the liver and muscle cells. When these and other body cells are saturated with glycogen, the excess glucose is converted into fat and stored as adipose tissue. See also hypoglycemia, hyperglycemia.

radioactive glucose used experimentally.
liquid glucose
a thick syrupy, sweet liquid, consisting chiefly of dextrose, with dextrins, maltose and water, obtained by incomplete hydrolysis of starch; used as a flavoring agent, as a food, and in the treatment of dehydration.
an intermediate in carbohydrate metabolism.
a liver (and kidney) enzyme that irreversibly cleaves glucose-6-phosphate to free glucose and phosphate; important in glucose homeostasis.
an intermediate in carbohydrate metabolism.
glucose-6-phosphate dehydrogenase (G6PD)
a regulatory enzyme in the metabolism of glucose-6-phosphate. A deficiency of the enzyme in the erythrocyte results in a hemolytic anemia; an inherited abnormality in humans, rats and mice and acquired in animals in phenothiazine toxicity and ingestion of kale.
glucose phosphate isomerase
converts glucose-6-phosphate to fructose-6-phosphate and the reverse reaction.
glucose suppression test
suppression of blood levels of growth hormone by the intravenous administration of glucose is used to diagnose acromegaly.
glucose tolerance factor (GTF)
a naturally occurring substance containing chromium which potentiates the effects of insulin.
glucose tolerance test
a test of the body's ability to utilize carbohydrates. It is often used to detect abnormalities of carbohydrate metabolism such as occur in diabetes mellitus, hypoglycemia, and liver and adrenocortical dysfunction. If administered orally, it may also be used to assess the absorptive capacity of the small intestine.
References in periodicals archive ?
Glucose-6-phosphatase gene mutations in Taiwan Chinese patients with glycogen storage disease type Ia.
It is the most common hereditary diseases of type I glycogen storage and, clinically, the most serious, where the cause of the disturbance is the absence of or diminishing of glucose-6-phosphatase of the liver, the intestinal mucosa, and the kidneys (2,3); leading to an accumulation of abnormally high amounts of glycogen in tissues like the liver and renal tubular cells, hence, through this mechanism producing hepatomegaly and nephromegaly (3,4), the first is well-described in both patients previously discussed and nephromegaly was noted in the younger patient.
It has been reported that glucose-6-phosphatase mRNA levels increase in liver after exposure to fructose even in the presence of physiological concentrations of glucose (24).
The fully-active nature of synthetic and hydrolytic activities of glucose-6-phosphatase of intact nuclear membrane.
According to data compiled by the Naturex Actifs Innovants department, Svetol works as a fat burner by decreasing the glucose intestinal absorption and by inhibiting the glucose-6-phosphatase (G-6-Pase) in the liver.
indica's insulin-like activity was related to modulating several glyolytic and lipolytic enzymes and the repression of the glucose-6-phosphatase enzyme (48).
1 ppm) concentrations of deltamethrin and at the end of the exposure periods, the fish were stunned to death and target organs like gill, liver and muscle were dissected out and glycogen phosphorylase was estimated by method of Sutherland (1955) and glucose-6-phosphatase was estimated by method of Yeung et al,.
Papers encompass experimental research in the biochemistry and pathophysiology of the endoplasmic reticulum, genetic and metabolic diseases, and new research on its functions such as the glucose-6-phosphatase system, development disorders, regulation, genes and proteins, redox homeostasis and control, metabolism, and oxidative stress.
However, the mammary tissue is unable to synthesize glucose from other precursors due to the lack of the enzyme glucose-6-phosphatase.
The activity of hexokinase is remarkably decreased while glucose-6-phosphatase and fructose 1, 6-bisphosphatase are significantly (p < 0.
Special clinical report on effects of glucose-6-phosphatase on human subjects.

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