The hepatic gluconeogenic enzymes glucose-6-phosphatase
(G6Pase) and fructose-1,6-bisphosphatase (F1,613Pase) were significantly increased in diabetic rats (Shulman 2000).
Table 5 Effect of 20-OH-ecdysorie on glucose-6-phosphatase
and fructose-1,6-bisphosphatase in the liver of control and diabetic rats.
ASAT, aspartate aminotrasnferase; ALAT, alanine aminotransferase; GDH, glutamate dehydrogenase; TD, threonine deaminase; ALP, alkaline phosphatase; [gamma]-GT, [gamma]-glutamyl-transferase; G-6-Pase, glucose-6-phosphatase
. All these liver enzyme activities are expressed in pmol/min/mg prot except for ALP, [gamma]-GT and G-6-Pase activities, which are expressed in nmol/min/mg prot.
Con: control group; FXR: farnesoid X receptor; SHP: small heterodimer partner; SREBP-1: sterol regulatory element binding protein-1; CYP7A1: cholesterol 7a-hydroxylase gene (CYP7A1); PEPCK: phosphoenolpyruvate carboxykinase; G6Pase: glucose-6-phosphatase
; PPARa: peroxisome-proliferator-activated receptor a.
[26.] Chatelain F, Pegorier JP, Minassian C, et al Development and regulation of glucose-6-phosphatase
gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.
(2002) Nutritional regulation of glucose-6-phosphatase
gene expression in liver of the gilthead sea bream (Sparus aurata).
Beaudet, "Type Ib glycogen storage disease is caused by a defect in the glucose-6-phosphate translocase of the microsomal glucose-6-phosphatase
system," The Journal of Biological Chemistry, vol.
(4) AFP is the most common elevated serological marker; however, LDH, a-1antitrypsin, glucose-6-phosphatase
, and CA 19-9 may also be abnormal.
The G272W mutation in the glucose-6-phosphatase
, catalytic subunit (G6PC) gene has been reported once in mainland China, but has not been reported in Taiwan or other countries.
Dehydroepiandrosterone suppresses elevated elevated hepatic glucose-6-phosphatase
mRNA level in C57BL/KsJdb/db mice: comparison with troglitazone.
Abbreviations LBP: Lycium barbarum polysaccharides CAT: Catalase GCK: Gluconokinase G6Pase: Glucose-6-phosphatase
GSH: Glutathione GSK3[beta]: Glycogen synthase kinase 3[beta] HFD: High-fat diet HO-1: Heme oxygenase 1 IRS-1: Insulin receptor substrate-1 JNK: Jun N-terminal kinases MCP: Monocyte chemotactic protein ND: Normal diet Nrf2: NF-E2-related factor 2 ROS: Reactive oxygen species PEPCK: Phosphoenolpyruvate carboxykinase PK: Pyruvate kinase PI3K: Phosphatidylinositol 3-kinase SOD2: Superoxide dismutase 2 TNF-[alpha]: Tumor necrosis factor alpha.
The zinc supplementation in patients with T2D improved insulin secretion, while suppressing glucagon and glucose-6-phosphatase