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Related to glucose-6-phosphatase: glucose-6-phosphate dehydrogenase


(glū'kōs fos'fă-tās),
A liver enzyme catalyzing the hydrolysis of d-glucose 6-phosphate to d-glucose and orthophosphate; this enzyme is deficient in glycogen storage disease Ia.
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References in periodicals archive ?
The hepatic gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and fructose-1,6-bisphosphatase (F1,613Pase) were significantly increased in diabetic rats (Shulman 2000).
Table 5 Effect of 20-OH-ecdysorie on glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver of control and diabetic rats.
ASAT, aspartate aminotrasnferase; ALAT, alanine aminotransferase; GDH, glutamate dehydrogenase; TD, threonine deaminase; ALP, alkaline phosphatase; [gamma]-GT, [gamma]-glutamyl-transferase; G-6-Pase, glucose-6-phosphatase. All these liver enzyme activities are expressed in pmol/min/mg prot except for ALP, [gamma]-GT and G-6-Pase activities, which are expressed in nmol/min/mg prot.
Con: control group; FXR: farnesoid X receptor; SHP: small heterodimer partner; SREBP-1: sterol regulatory element binding protein-1; CYP7A1: cholesterol 7a-hydroxylase gene (CYP7A1); PEPCK: phosphoenolpyruvate carboxykinase; G6Pase: glucose-6-phosphatase; PPARa: peroxisome-proliferator-activated receptor a.
[26.] Chatelain F, Pegorier JP, Minassian C, et al Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.
Beaudet, "Type Ib glycogen storage disease is caused by a defect in the glucose-6-phosphate translocase of the microsomal glucose-6-phosphatase system," The Journal of Biological Chemistry, vol.
(4) AFP is the most common elevated serological marker; however, LDH, a-1antitrypsin, glucose-6-phosphatase, and CA 19-9 may also be abnormal.
The G272W mutation in the glucose-6-phosphatase, catalytic subunit (G6PC) gene has been reported once in mainland China, but has not been reported in Taiwan or other countries.
Abbreviations LBP: Lycium barbarum polysaccharides CAT: Catalase GCK: Gluconokinase G6Pase: Glucose-6-phosphatase GSH: Glutathione GSK3[beta]: Glycogen synthase kinase 3[beta] HFD: High-fat diet HO-1: Heme oxygenase 1 IRS-1: Insulin receptor substrate-1 JNK: Jun N-terminal kinases MCP: Monocyte chemotactic protein ND: Normal diet Nrf2: NF-E2-related factor 2 ROS: Reactive oxygen species PEPCK: Phosphoenolpyruvate carboxykinase PK: Pyruvate kinase PI3K: Phosphatidylinositol 3-kinase SOD2: Superoxide dismutase 2 TNF-[alpha]: Tumor necrosis factor alpha.
The zinc supplementation in patients with T2D improved insulin secretion, while suppressing glucagon and glucose-6-phosphatase levels [69].

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