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Related to glucose-6-phosphatase: glucose-6-phosphate dehydrogenase


(glū'kōs fos'fă-tās),
A liver enzyme catalyzing the hydrolysis of d-glucose 6-phosphate to d-glucose and orthophosphate; this enzyme is deficient in glycogen storage disease Ia.


/glu·cose-6-phos·pha·tase/ (fos´fah-tās″) an enzyme that catalyzes the hydrolytic dephosphorylation of glucose 6-phosphate, the principal route for hepatic gluconeogenesis; deficiency causes glycogen storage disease, type I.

glucose, d-glucose

a simple sugar, a monosaccharide in certain foodstuffs, especially fruit, and in normal blood; the major source of energy for many living organisms. See also dextrose.
Glucose, whose molecular formula is C6H12O6, is the end product of carbohydrate digestion; other monosaccharides (fructose and galactose) are largely converted into glucose. Glucose is the only monosaccharide present in significant amounts in the body fluids. The oxidation of glucose produces energy for the body cells; the rate of metabolism is controlled by a number of hormones the most important of which are insulin and glucagon. Glucose that is not needed for energy is stored in the form of glycogen as a source of potential energy, readily available when needed. Most of the glycogen is stored in the liver and muscle cells. When these and other body cells are saturated with glycogen, the excess glucose is converted into fat and stored as adipose tissue. See also hypoglycemia, hyperglycemia.

radioactive glucose used experimentally.
liquid glucose
a thick syrupy, sweet liquid, consisting chiefly of dextrose, with dextrins, maltose and water, obtained by incomplete hydrolysis of starch; used as a flavoring agent, as a food, and in the treatment of dehydration.
an intermediate in carbohydrate metabolism.
a liver (and kidney) enzyme that irreversibly cleaves glucose-6-phosphate to free glucose and phosphate; important in glucose homeostasis.
an intermediate in carbohydrate metabolism.
glucose-6-phosphate dehydrogenase (G6PD)
a regulatory enzyme in the metabolism of glucose-6-phosphate. A deficiency of the enzyme in the erythrocyte results in a hemolytic anemia; an inherited abnormality in humans, rats and mice and acquired in animals in phenothiazine toxicity and ingestion of kale.
glucose phosphate isomerase
converts glucose-6-phosphate to fructose-6-phosphate and the reverse reaction.
glucose suppression test
suppression of blood levels of growth hormone by the intravenous administration of glucose is used to diagnose acromegaly.
glucose tolerance factor (GTF)
a naturally occurring substance containing chromium which potentiates the effects of insulin.
glucose tolerance test
a test of the body's ability to utilize carbohydrates. It is often used to detect abnormalities of carbohydrate metabolism such as occur in diabetes mellitus, hypoglycemia, and liver and adrenocortical dysfunction. If administered orally, it may also be used to assess the absorptive capacity of the small intestine.
References in periodicals archive ?
Activities of hexokinase and pyruvate kinase, glucose-6-phosphatase (G6Pase) and fructose 1, 6-bisphosphatase (F16BPase) in liver and skeletal muscle of experimental animals Parameters CON FRU Liver: Hexokinase (A) 0.
Diabetic rats (group II) showed decreased activity of glucokinase and increased activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver.
Interfere with glucose-6-phosphatase, an enzyme involved in creation of often surplus blood glucose from protein and fats (19)
Diabetic rats showed decreased activity of hexokinase, and, increased activities of glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase.
The cortisol-induced metabolic abnormalities includes many mechanisms, mainly impaired insulin sensitivity, altered lipid metabolism, enhanced adipogenesis and gluconeogenesis; gluconeogenesis is increased due to increased hepatic phospho-enolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase enzymes activities (Radahmadi et al.
11[beta]HSD-1 is mainly found in the tissues such as liver, adipose, skeletal muscle, brain and immune system, over expression or increased activity of 11[beta]-HSD-1 leads to increase in cortisol levels in the body; especially in liver increased activity of 11[beta]-HSD-1 leads to increase in gluconeogenesis through the activation of hepatic phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase activity (Radahmadi et al.
The altered activities of key enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase of carbohydrate metabolism significantly (p <0.
Effect of 20-OH-ecdysone on the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase
As reviewed by Van Dam (2006), chlorogenic acid has been described as increasing hepatic glucose uptake as well as reducing hepatic glucose output by inhibiting glucose-6-phosphatase.

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