Robertson, "A role for glutathione peroxidase in protecting pancreatic [beta] cells against oxidative stress in a model of glucose toxicity
," Proceedings of the National Academy of Sciences of the United States of America, vol.
in -cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection.
These correlations suggested COE may enhance antioxidant capacity of treated diabetic model mice by decreasing the glucose toxicity
[25.] Lorenzi et al; Glucose Toxicity
for human Endothelial Cells.
Specifically, we assessed: (1) deoxyglucose uptake in differentiated C2C12 muscle cells and 3T3-L1 adipocytes; (2) glucose-stimulated insulin secretion (GSIS) in beta TC-tet pancreatic beta cells; (3) beta cell proliferation in beta TC-tet cells; (4) lipid accumulation in differentiating 3T3-L1 cells; (5) protection against glucose toxicity
in PC12 cells.
Beneficial effects of antioxidants in diabetes; possible protection of pancreatic beta-cells against glucose toxicity
. Diabetes 48, 2398-2406.
This finding might be of relevance to the natural history of type 2 diabetes because glucose toxicity
attributable to chronic hyperglycemia per se impairs both insulin action and insulin secretion (32).
Not only does it bring down blood glucose, it may act synergistically with other agents to reduce glucose toxicity
. Moreover, there is some evidence to suggest that starting insulin early in the course of the disease may help preserve beta-cell function, thus providing a "type 2 honeymoon" effect.
EFFECT OF GLYCATION REVERSAL AGENTS ON GLUCOSE TOXICITY
IN A HALOPHILIC BACTERIUM ISOLATED FROM AN INLAND SALT SPRING.
Although pancreatic beta cell glucose toxicity
is usually characterized as an impairment of beta cell functions induced by chronic constant high glucose, more and more studies have suggested intermittent high glucose (IHG) to be more dangerous for further [beta]-cell dysfunction and the development of diabetes.
Multiple biochemical pathways and mechanisms of action of glucose toxicity
have been suggested.
Low levels are not necessarily an indication of type 1, however, because patients with type 2 diabetes may have low levels of insulin and C-peptide because of glucose toxicity
and lipotoxicity at the time of diagnosis.