Efficacy and safety of glucosamine sulfate
versus ibuprofen in patients with knee osteoarthritis.
These effects have been observed to be more consistent with glucosamine sulfate
rather than hydrochloride .
Antiarthritic effects of glucosamine sulfate
studied in animal models.
Table 1 Review Inclusion Criteria * Published in English * Published in a peer-reviewed journal * Published in the past 25 years (1984-2009) * Randomized controlled trial * Patients must have spinal osteoarthritis / osteoarthrosis / degenerative joint disease and/or degenerative disc disease proven via diagnostic imaging * Use glucosamine sulfate
(or glucosamine HCl) and/or chondroitin sulfate and/or methylsulfonylmethane (MSM) * Use of other medications, supplements, or interventions tolerable * Comparison group could consist of a do nothing control, placebo, or a different active treatment * Outcome measures include an assessment of pain and/or disability due to pain Table 2 Jadad Scale Scoring Results Leffler CT, et Fujita T, et al.
However a topical application of a preparation containing glucosamine sulfate
, chondroitin sulfate, and shark cartilage reduced, within 4 weeks, pain related to knee OA to a significantly greater extend than a placebo cream.
While the clinical significance of these findings is not certain, glucosamine sulfate
and glucosamine hydrochloride should be used with caution in patients with elevated or high-normal IOP and in patients with glaucoma.
Glucosamine is widely used in the United States as a dietary supplement, most often as glucosamine sulfate
but also as n-acetyl glucosamine and glucosamine hydrochloride, although there is limited evidence of effectiveness for the latter formulations.
: Eases pain and inflammation; helps rebuild damaged cartilage.
The study assessed the effectiveness of two interventions: a weight-reduction program and oral glucosamine sulfate
WHAT'S IN IT: Eight ingredients commonly found in arthritis supplements, including glucosamine sulfate
, MSM, white willow bark extract, ginger, cayenne pepper, and hyaluronic acid.
She uses glucosamine sulfate
with MSM for her arthritis, which she says is under control, and ginkgo for her memory.