glucokinase


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glucokinase

 [gloo″ko-ki´nās]
an enzyme that in the presence of ATP catalyzes glucose to glucose-6-phosphate.

glu·co·ki·nase

(glū'kō-kī'nās), [MIM*138079]
Phosphotransferase that catalyzes the conversion of d-glucose and ATP to d-glucose 6-phosphate and ADP; the liver enzyme has a higher Km value for d-glucose than hexokinase and is not strongly inhibited by the product d-glucose 6-phosphate.

GCK

A gene on chromosome 7p15.3-p15.1 that encodes a glucokinase (hexokinase) that phosphorylates glucose yielding glucose-6-phosphate, the first usual step in glucose metabolism.

Molecular biology
GCK mutations are linked to type-2 diabetes, maturity-onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycaemia of infancy (PHHI).

glu·co·ki·nase

(glū'kō-kī'nās)
Phosphotransferase that catalyzes the conversion of d-glucose and adenosine triphosphate d-glucose 6-phosphate and adenosine diphosphate; the liver enzyme has a higher Km value for d-glucose than does hexokinase.

glu·co·ki·nase

(glū'kō-kī'nās) [MIM*138079]
Phosphotransferase that catalyzes the conversion of d-glucose and adenosine triphosphate d-glucose 6-phosphate and adenosine diphosphate.
References in periodicals archive ?
Kubota et al., "Glucokinase and IRS-2 are required for compensatory [beta] cell hyperplasia in response to high-fat diet-induced insulin resistance," Journal of Clinical Investigation, vol.
If impaired beta cell regulation of [K.sub.ATP] channel activity or glucokinase activity or HNF activity was the only problem in type 2 diabetes, then its phenotype would resemble that of patients with neonatal diabetes or GCK or HNF mutations, which it does not.
Missense mutations have variable effects on glucokinase activity ranging from a small change in affinity for glucose to complete inactivity (19).
The higher activities of glucokinase and the lower activities of hepatic mitochondrial pyruvate dehydrogenase lead to increasing the uptake of hepatic glucose and the rates of glycolysis in livers of arthritic rats [67].
Immunodetection of glucokinase (GCK), fructokinase (FK), phosphofructokinase-2 (PFK2), and ACTINB was performed with liver homogenates from each experimental group.
Diabetic rats (group II) showed decreased activity of glucokinase and increased activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver.
Liver glucokinase (GCK) and pyruvate kinase (PK) activities were measured with the Assay Kit (Nanjing Jiancheng Bioengineering Institute, China) according to the manufacture's instruction.
It is suggested that hyperglycemic effect produced is due to mobilization of glycogen in the liver which may be due to direct inhibition of glucokinase or indirectly by stimulating the release
An altered ability to sense the environment can produce hormone deficiency (e.g., glucokinase mutations producing maturity-onset diabetes of the young 2).
Under the terms of the agreement between the companies, Amgen obtained exclusive worldwide rights to Array's small-molecule glucokinase activator programme, including ARRY-403, which is currently being tested in a Phase I clinical trial in patients with type 2 diabetes.
It may reduce atherosclerotic lesions; and it modifies genomic expressions, for example, glucokinase. It is an important cofactor to several enzymes, including acetyl CoA carboxylase and other carboxylases.