glucocorticoid resistance


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glucocorticoid resistance

defective response of target tissues to glucocorticoids; a common acquired state frequently associated with allergic or autoimmune conditions (for example, asthma or rheumatoid arthritis) or severe inflammatory states (for example, respiratory distress syndrome or septic shock); also occurs as a rare genetic syndrome resulting from malfunction of glucocorticoid receptor.

glucocorticoid resistance

1. A rare genetically inherited insensitivity of peripheral tissues to the effects of steroid hormones produced by the adrenal cortex. Affected patients produce excessive compensatory quantities of ACTH and may be affected by hyperandrogenism or mineralocorticoid excess.
2. Insensitivity to treatment with glucocorticoid drugs, e.g., prednisone for asthma or Crohn disease.
See also: resistance
References in periodicals archive ?
These results suggested that SQV plus glucocorticoids can resolve systemic inflammation to a large degree by inhibiting the decrease of GR[alpha] and I[kappa]B[alpha] in the cytoplasm, thus improving glucocorticoid resistance as well.
Hulleman et al., "Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia," Leukemia, vol.
Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates.
Social stress induces glucocorticoid resistance in subordinate animals.
However, the constant increase in the number of patients suffering from glucocorticoid resistance could present a serious problem for clinicians.
The long-term effect results in glucocorticoid resistance, a condition well described in MD, FM CFS, and NP.

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