glucocorticoid resistance


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glucocorticoid resistance

defective response of target tissues to glucocorticoids; a common acquired state frequently associated with allergic or autoimmune conditions (for example, asthma or rheumatoid arthritis) or severe inflammatory states (for example, respiratory distress syndrome or septic shock); also occurs as a rare genetic syndrome resulting from malfunction of glucocorticoid receptor.

glucocorticoid resistance

1. A rare genetically inherited insensitivity of peripheral tissues to the effects of steroid hormones produced by the adrenal cortex. Affected patients produce excessive compensatory quantities of ACTH and may be affected by hyperandrogenism or mineralocorticoid excess.
2. Insensitivity to treatment with glucocorticoid drugs, e.g., prednisone for asthma or Crohn disease.
See also: resistance
References in periodicals archive ?
Social stress induces glucocorticoid resistance in subordinate animals.
Via direct action on the brain, glucocorticoid resistance augments inflammation and further stimulates HPA axis activity in a vicious cycle.
In conclusion glucocorticoid resistance is important in several inflammatory diseases, including RA, and this complicates their clinical management.

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