glucagonoma


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Related to glucagonoma: glucagonoma syndrome

glucagonoma

 [gloo″kah-gon-o´mah]
a glucagon-secreting tumor of the alpha cells of the islets of Langerhans.

glu·ca·gon·o·ma

(glu'kă-gon-ō'mă),
A glucagon-secreting tumor, usually derived from pancreatic islet cells.

glucagonoma

/glu·ca·gon·o·ma/ (gloo″kah-gon-o´mah) an islet cell tumor of the alpha cells that secretes glucagon.

glucagonoma

A pancreatic alpha-cell tumour with 2 distinct clinicopathologic patterns:
(1) Benign—not associated with glucagonoma syndrome, which has a bland, gyriform histology.
(2) Glucagon-producing neuroendocrine neoplasms of the pancreas, associated with the clinical syndrome of:
• Hyperglycaemia;
• Anaemia, diarrhoea, weight loss;
• Hypoaminoacidemia;
• Necrolytic migratory erythema.

Prognosis
Poor: up to 75% of glucagonoma patients die of disease.

glu·ca·gon·o·ma

(glu'kă-gon-ō'mă)
A glucagon-secreting tumor, usually derived from pancreatic islet cells.

glucagonoma

a glucagon-secreting tumor of the alpha cells of the islets of Langerhans.
References in periodicals archive ?
Three additional glucagonomas with sizes ranging from 0.
111]In octreotide scintigraphy is highly dependent on the histological subtype of the tumor, ranging from 46% for insulinomas to 100% for glucagonomas, (3) causing false-negatives to occur in a significant proportion, especially in MEN-1 patients who present numerous lesions.
Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome.
The glucagonoma syndrome: a review of its features and discussion of new perspectives.
The glucagonoma syndrome and necrolytic migratory erythema: a clinical review.
Glucagonoma was confirmed and resolution of chronic tachycardia and rash occurred after resection.
In managing patients with glucagonoma, we advocate a preoperative echocardiogram to exclude or confirm cardiomyopathy, especially in those patients that have unexplained tachycardia or congestive heart failure.
The glucagonoma syndrome includes increased hepatic gluconeogenesis and hyperglycemia, muscle catabolism with associated wasting, and an unusual cutaneous eruption known as necrolytic migratory erythema, sometimes with associated stomatitis or cheilosis.
To our knowledge, there has been only one other report of bone metastases as the initial clinical manifestation of glucagonoma.
These tumors are classified according to the predominant hormone of oversecretion: insulinoma, gastrinoma, vasoactive intestinal peptide-secreting tumors (VIPoma), glucagonoma, somatostatinoma, and growth-hormone-releasing factor-secreting tumors (GRFomas).
51,52) They can be categorized into hyperfunctioning (insulinoma, gastrinoma, glucagonoma, vipoma, and somatostatinoma) and nonhyperfunctioning tumors that can be located in the pancreas or peripancreatic tissue.
102,129,130) Indeed, mutations are detected in about 30% of NF-PENs, whereas insulinomas, gastrinomas, glucagonomas, and VIPomas show a mutation rate of 7%, 36%, 67%, and 44%, respectively.