glucagonoma


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Related to glucagonoma: glucagonoma syndrome

glucagonoma

 [gloo″kah-gon-o´mah]
a glucagon-secreting tumor of the alpha cells of the islets of Langerhans.

glu·ca·gon·o·ma

(glu'kă-gon-ō'mă),
A glucagon-secreting tumor, usually derived from pancreatic islet cells.

glucagonoma

A pancreatic alpha-cell tumour with 2 distinct clinicopathologic patterns:
(1) Benign—not associated with glucagonoma syndrome, which has a bland, gyriform histology.
(2) Glucagon-producing neuroendocrine neoplasms of the pancreas, associated with the clinical syndrome of:
• Hyperglycaemia;
• Anaemia, diarrhoea, weight loss;
• Hypoaminoacidemia;
• Necrolytic migratory erythema.

Prognosis
Poor: up to 75% of glucagonoma patients die of disease.

glu·ca·gon·o·ma

(glu'kă-gon-ō'mă)
A glucagon-secreting tumor, usually derived from pancreatic islet cells.
References in periodicals archive ?
These staining confirmed the diagnosis of glucagonoma with degree of differentiation G1 and pT2 N1 M0 stage IIB.
NME is a presenting feature in 70% of patients with glucagonoma. It
Distinctive dermatosis of the glucagonoma syndrome.
Necrolytic migratory erythema without glucagonoma: the role of dietary essential fatty acids.
Depressive symptoms are present in patients with glucagonoma. Glucagonoma is an alpha-islet cell tumour of the pancreas.
Glucagonoma are rare slow-growing tumours of the pancreatic alpha cells that cause hypersecretion of glucagon with an incidence estimated to be one in 20 million people per annum.
O ENM e caracteristico da sindrome glucagonoma, sendo observado em pacientes com neoplasmas pancreaticos secretores de glucagon ou, mais raramente, com cirrose hepatica e outras doencas gastrintestinais (BYRNE, 1999; PUJOL et al., 2004).
Cushing's disease, acromegaly, pheochromocytoma, and glucagonoma are rare causes of insulin resistance to consider in the work-up of brittle diabetes.
Increased lactate dehydrogenase isoenzyme-1 in a case of glucagonoma. Clin Chem 1994;40:158-9.
The following types of hormone tumors were identified by these methods: papillary, follicular, and medullary carcinomas of the thyroid, gastrinoma, insulinoma, glucagonoma, merkel cell tumor, several carcinoids, small cell anaplastic carcinoma, prolactinoma, and growth hormone tumors.
Glucagonoma is a rare, slowly growing, frequently malignant pancreatic neuroendocrine tumor (NET) arising from alpha-cells of the islets of the Langerhans.
Case 1, intrapancreatic accessory spleen; Case 2, pancreatic glucagonoma