glucagonoma


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Related to glucagonoma: glucagonoma syndrome

glucagonoma

 [gloo″kah-gon-o´mah]
a glucagon-secreting tumor of the alpha cells of the islets of Langerhans.

glu·ca·gon·o·ma

(glu'kă-gon-ō'mă),
A glucagon-secreting tumor, usually derived from pancreatic islet cells.

glucagonoma

/glu·ca·gon·o·ma/ (gloo″kah-gon-o´mah) an islet cell tumor of the alpha cells that secretes glucagon.

glucagonoma

A pancreatic alpha-cell tumour with 2 distinct clinicopathologic patterns:
(1) Benign—not associated with glucagonoma syndrome, which has a bland, gyriform histology.
(2) Glucagon-producing neuroendocrine neoplasms of the pancreas, associated with the clinical syndrome of:
• Hyperglycaemia;
• Anaemia, diarrhoea, weight loss;
• Hypoaminoacidemia;
• Necrolytic migratory erythema.

Prognosis
Poor: up to 75% of glucagonoma patients die of disease.

glu·ca·gon·o·ma

(glu'kă-gon-ō'mă)
A glucagon-secreting tumor, usually derived from pancreatic islet cells.

glucagonoma

a glucagon-secreting tumor of the alpha cells of the islets of Langerhans.
References in periodicals archive ?
Glucagonoma, due to oversecretion of glucagon is associated with a characteristic paraneoplastic phenomenon, called glucagonoma syndrome, which consists of specific rash known as necrolytic migratory erythema (NME), mild diabetes mellitus (DM), weight loss, normochromic normocytic anemia, glossitis, stomatitis, hypoaminoacidemia, deep vein thrombosis and depression [7].
NME is a presenting feature in 70% of patients with glucagonoma.
Three additional glucagonomas with sizes ranging from 0.
Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome.
The glucagonoma syndrome and necrolytic migratory erythema: a clinical review.
Glucagonoma was confirmed and resolution of chronic tachycardia and rash occurred after resection.
Necrolytic migratory erythema without glucagonoma versus canine superficial necrolytic dermatitis: Is hepatic impairment a clue to pathogenesis?
We describe an unusual case of a patient with glucagonoma who presented with a pathologic vertebral fracture.
The following types of hormone tumors were identified by these methods: papillary, follicular, and medullary carcinomas of the thyroid, gastrinoma, insulinoma, glucagonoma, merkel cell tumor, several carcinoids, small cell anaplastic carcinoma, prolactinoma, and growth hormone tumors.
Pancreatic neuroendocrine tumors Tumor Prevalence Malignancy Rate amongst PETs Insulinoma 40% 10% Gastrinoma 20% 60% Non-Functioning 35% 85% Glucagonoma Rare 80% VIPoma Rare 70% Somatistatinoma Rare 70% Tumor Clinical Symptoms, Features Insulinoma Hypoglycemia, elevated serum C-peptide Gastrinoma Gastric hypersecretion leading to post/bulbar ulcers and diarrhea.
Her diagnosis was glucagonoma syndrome, a rare [alpha]-cell tumor of the pancreas; there are only about 400 reported cases.