Atubular glomeruli and glomerulotubular
junction abnormities is diabetic nephropathy.
10) However, the glomerulotubular junction is almost always stenotic in glomeruli with periglomerular fibrosis, and the adjoining proximal tubule is usually atrophic.
These atrophic, proximal tubules may preserve a narrow connection to the Bowman capsule but are frequently completely cut off at the glomerulotubular junction (atubular glomeruli) (Figure 2, B and C).
Many of these glomeruli are atubular glomeruli (glomeruli with no connection to a proximal tubule) but, in selected cases, we have performed serial sectioning and proved that many of these glomeruli do have existing, but stenotic, glomerulotubular junctions.
18) The epithelium at the glomerulotubular junction may play a particularly important role.
This is because the changes in GFR are small and these changes automatically induce proportional changes in sodium reabsorption by the proximal tubule, a phenomenon known as glomerulotubular
202,203) Another proposed mechanism for cyst formation is stenosis at the glomerulotubular junction.
The glomerulotubular junction: a target in renal diseases.
Selected resin blocks for EM (see later) with glomeruli were serially sectioned to examine the glomerulotubular junction.
Periglomerular fibrosis is not always associated with complete occlusion of the glomerulotubular junction, as seen on serial sections.
Atubular glomeruli are glomeruli that are disconnected from their proximal tubule at the glomerulotubular junction, or those that have just a short length of proximal tubule, with narrowing or obstruction along the length of the tubule because of tubular injury/interstitial fibrosis.
Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes.