glomerulosclerosis

Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.

Related to glomerulosclerosis: focal segmental glomerulosclerosis

glomerulosclerosis

[glo-mer″u-lo-sklĕ-ro´sis]

diabetic glomerulosclerosis (intercapillary glomerulosclerosis) a degenerative complication of diabetes mellitus in which there is glomerular mesangial expansion with either diffuse lesions or nodular (Kimmelstiel-Wilson) lesions; symptoms include albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy. The type with nodular lesions is also called Kimmelstiel-Wilson syndrome.

focal segmental glomerulosclerosis focal sclerosing lesions of the renal glomeruli, with proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another condition. Called also focal glomerular sclerosis.

glo·mer·u·lo·scle·ro·sis

(glō-mer'yū-lō-sklē-rō'sis),

Hyaline deposits or scarring within the renal glomeruli, a degenerative process occurring in association with renal arteriosclerosis or diabetes.

Synonym(s): glomerular sclerosis

[glomerulus + G. sklērōsis, hardness]

glomerulosclerosis

/glo·mer·u·lo·scle·ro·sis/ (glo-mer″u-lo-sklĕ-ro´sis) fibrosis and scarring resulting in senescence of the renal glomeruli.

diabetic glomerulosclerosis intercapillary g.

focal segmental glomerulosclerosis a syndrome of focal sclerosing lesions of the renal glomeruli with proteinuria, hematuria, hypertension, and nephrosis, with variable progression to end-stage renal disease.

intercapillary glomerulosclerosis a degenerative complication of diabetes, manifested as albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy.

glomerulosclerosis

[-sklərō′sis]

Etymology: L, glomerulus, small ball; Gk, sklerosis, a hardening, osis, condition

a severe kidney disease in which glomerular function of blood filtration is lost as fibrous scar tissue replaces the glomeruli. The disease commonly follows an infection or arteriosclerosis.

Glomerulosclerosis

glomerulosclerosis

Nephrology A degenerative lesion of the renal glomeruli caused by ASHD or DM. See Kimmelsteil-Wilson disease.

glo·mer·u·lo·scle·ro·sis

(glō-mer'yū-lō-skler-ō'sis)

Hyaline deposits or scarring within the renal glomeruli, a degenerative process occurring in association with renal arteriosclerosis or diabetes mellitus.

[glomerulus + G. sklērōsis, hardness]

glomerulosclerosis

A kidney disease in which many glomeruli (see GLOMERULUS), previously damaged by inadequate blood supply or GLOMERULONEPHRITIS, become replaced by a non-functioning glassy (hyaline) material. It sometimes occurs without prior damage. The effects resemble those of the NEPHROTIC SYNDROME and kidney function gradually deteriorates. Kidney failure is a common outcome.

glomerulosclerosis

renal glomerulus degeneration and fibrosis; associated with arteriosclerosis and diabetes

glomerulosclerosis

progressive hyalinization such that glomeruli become shrunken, eosinophilic and hypocellular masses.

intercapillary glomerulosclerosis

see kimmelstiel-wilson syndrome.

References in periodicals archive ?

In addition, although rare, malignancy and specifically renal cell carcinoma have been associated with a number of paraneoplastic glomerular diseases including immunoglobulin A nephropathy, focal segmental glomerulosclerosis, membranous glomerulonephropathy, minimal change disease, secondary amyloidosis, and crescentic glomerulonephritis.

Nonneoplastic renal cortical scarring at tumor nephrectomy predicts decline in kidney function

In our investigation we found that chronic exercise attenuated glomerulosclerosi index and it was associated with decreased sympathetic nerve activity and reduction of AP.

Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats

Urinary podocytes in primary focal segmental glomerulosclerosis.

A mutant Ahr allele protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming

Histologically, this group is divided into the 'classic' HIV-associated nephropathy (HIVAN) with focal segmental glomerulosclerosis (HIV-FGS), HIV-associated immune complex disease (HIV-IC), and HIV-associated thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (HIV-TTP/HUS).

HIV infection and the kidney

Histological findings consisted of focal and segmental glomerulosclerosis and minimal change disease.

Renal failure in malaria

The problem was Focal Segmental Glomerulosclerosis (FSGS), a rare kidney disease Morgan has been battling since she was four.

Principal offers kidney

They include attenuation of the development of glomerulosclerosis and retarding the progression of albuminuria.

The physiology of vitamin D: current concepts

glomerulosclerosis, scarring or hardening of tiny blood vessels in the kidney

Urinary Tract Conditions; Overview

Renal problems, such as acute renal failure resulting from rhabdomyolysis and end-stage renal failure resulting from focal segmental glomerulosclerosis, further increase morbidity.

Mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome (MELAS): a case report, presentation, and management

Smith, 25 years old, has end stage renal disease secondary to focal segmental glomerulosclerosis (FSGS) and had a deceased donor renal transplant two years ago.

Clinical educators network nursing recommendations for management of vascular access in hemodialysis patients

High-osmolar contrast media can enhance the progression of glomerulosclerosis and renal failure in old, spontaneously hypertensive male rats.

Contrast-medium-induced nephrotoxicity

The patent claims cover their potential utility in treating pathologies of aging and diabetes, including hypertension, retinopathy, cataracts, diabetic kidney disease, glomerulosclerosis, peripheral vascular disease, arteriosclerosis, peripheral neuropathy, stroke, atherosclerosis, osteoarthritis and the loss of elasticity and wrinkling of the skin.

Alteon issued patent covering protein-glucose products to treat diseases of aging and diabetes