Levay-Young, "Changes in the glomerulosa cell
phenotype during adrenal regeneration in rats," American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol.
Angiotensin converting enzyme (ACE), present in lung converts Angiotensin I into Angiotensin II.8 This angiotensin II via G protein coupled receptor in the glomerulosa cells
causes membrane depolarisation, activation and opening of calcium gated channels.
Adenosine increases interleukin 6 release and decreases tumour necrosis factor release from rat adrenal zona glomerulosa cells
, ovarian cells, anterior pituitary cells, and peritoneal macrophages.
Hyperkalemia stimulates aldosterone secretion by depolarization of the zona glomerulosa cells
and hypokalemia inhibits such depolarization.
Gallo-Payet, "Role of MAPKs in angiotensin II-induced steroidogenesis in rat glomerulosa cells
," Molecular and Cellular Endocrinology, vol.
However, populations of G cells in culture might be composed of different cell types (capsule, subcapsular, and glomerulosa cells
), so the difference in the regulation of Sf-1 and other genes in POD-1-transfected G cells compared with POD-1-transfected F/R cells shown here is not surprising.
In normal physiology, zona glomerulosa cells
are typically hyperpolarized because of predominant potassium conductance, primarily mediated by K+ channels (A).
The histological data of myelolipoma associated with primary hyperaldosteronism showed high plasma aldosterone, hypokalemia and suppressed plasma renin activity; the histological study showed a myelolipoma with hyperplasia of glomerulosa cells
Several investigators have suggested that major physiological stimulation of aldosterone production by the adrenal zona glomerulosa cells
, angiotensin II and potassium, are to a varying degree dependant on extracellur calcium influx to achieve maximum stimulation [18, 19].
Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome P450scc and 3[beta]-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells
Effects of angiotensin II on sodium potassium pumps, endogenous ouabain and aldosterone in bovine zona glomerulosa cells
. Hypertension 1999;33:373-7.