Parathyroid hormone modulates angiotensin II-induced aldosterone secretion from the adrenal glomerulosa cell.
PTH stimulates aldosterone secretion from adrenal glomerulosa cells in a dose-dependent manner, both alone and in combination with angiotensin II.
Hyperkalemia stimulates aldosterone secretion by depolarization of the zona glomerulosa cells
and hypokalemia inhibits such depolarization.
Gallo-Payet, "Role of MAPKs in angiotensin II-induced steroidogenesis in rat glomerulosa cells
," Molecular and Cellular Endocrinology, vol.
In normal physiology, zona glomerulosa cells
are typically hyperpolarized because of predominant potassium conductance, primarily mediated by K+ channels (A).
The histological data of myelolipoma associated with primary hyperaldosteronism showed high plasma aldosterone, hypokalemia and suppressed plasma renin activity; the histological study showed a myelolipoma with hyperplasia of glomerulosa cells
Several investigators have suggested that major physiological stimulation of aldosterone production by the adrenal zona glomerulosa cells
, angiotensin II and potassium, are to a varying degree dependant on extracellur calcium influx to achieve maximum stimulation [18, 19].
Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome P450scc and 3[beta]-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells
Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells
Effects of angiotensin II on sodium potassium pumps, endogenous ouabain and aldosterone in bovine zona glomerulosa cells
Separate induction of the two isozymes of cytochrome P-450(11) beta in rat adrenal zona glomerulosa cells
Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells
," Developmental Cell, vol.