Nucleotide Phenotype Reference Change m.5874A>G Ptosis, limb weakness, exercise Pulkes T, intolerance with complex III Neurology 2000 deficiency m.5885delT Chronic progressive external Raffelsberger T, ophthalmoplegia, myopathy and Neurology 2001 exercise intolerance m.5877G>A Chronic progressive external Sahashi T, Journal ophthalmoplegia, proximal of medical muscle weakness genetics 2001 m.5843A>G Focal segmental
glomerulo- Scaglia F, American sclerosis, cardiomyopathy journal of medical genetics 2003 m.5835G>A Chronic progressive external Kornblum C Bioscience ophthalmoplegia reports 2008 m.5835G>A Limb girdle muscle weakness, Present case swallowing impairment
Oxidative stress is involved in a plethora of diseases affecting renal apparatus such as
glomerulo- and tubule-interstitial nephritis, renal failure, proteinuria, and uremia [16, 42].