glomerular filtration barrier


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Related to glomerular filtration barrier: Bowman's capsule, urinary space, Glomerular capillaries

glomerular filtration barrier

The structure of the renal glomerulus that prevents the loss of proteins in the urine, thereby preserving albumin and globulins in the plasma instead of letting them leach into the urine.
See also: barrier
References in periodicals archive ?
Glomerular filtration barrier. Curr Opin Nephrol Hypertens.
Podocytes are the important components of the glomerular filtration barrier that prevents the excretion of albumin into the urine [21].
The glomerular filtration barrier is permanently exposed to hydrostatic pressure gradient across the capillaries, and therefore, the integrity of the interaction between the podocytes and the GBM is essential for the filtration to occur.
As podocytes play an important role in the structural and functional integrity of glomerular filtration barrier (GFB), any injury to the podocyte not only affects the structure of the podocyte or SD, but also disrupts the adjacent structures and consequently alters glomerular perm selectivity to the macromolecules in the blood.4,7
Glomerular filtration barrier damage plays a critical role in proteinuria in chronic kidney disease [3], which contains fenestrated endothelium, glomerular basement membrane (GBM), and slit diaphragm (SD) [4].
The most important event that precedes renal injury is an increase in permeability of plasma proteins such as albumin through a damaged glomerular filtration barrier. This results in excessive urinary albumin excretion (UAE) through the nephron.
Previous studies have reported that podocytes are highly differentiated, insulin-dependent glomerular epithelial cells contributing to glomerular filtration barrier [2].