In brief, in the course of a thermal melting of most
globular proteins of modest dimensions, including [alpha]-CT, the native and "normally" unfolded states can be considered as yet dominantly populated states against the relatively minor, thermally induced molten globule (predenatured) [25, 34], "intermediate" (metastable transitional) [16, 34], and misfolded/self-aggregated (postdenatured) states [16, 29, 35].
0])) was plotted against the logarithm of the MW of
globular proteins and purified cardiac troponin standards.
Several implications of the epitope analysis we have performed argue against hcTnI being globular, at least in the uncomplexed form that was used for immunization: (a) all 16 anti-hcTnI mAbs recognized a continuous epitope markedly; this contrasts with the observation that most mAbs to
globular proteins show a conformation-dependent recognition [12] and, therefore, do not react with short peptides; (b) several helices of hcTnI are antigenic, which means that they are probably exposed to the solvent and not packed together as in
globular proteins; and (c) we observed that regions connecting the predicted helices of hcTnI are not antigenic; this is in sharp contrast with the fact that turn regions in
globular proteins are generally antigenic.
In natural states, proteins generally exist in two form fibrous proteins and
globular proteins [138].
Many
globular proteins undergo conformation changes after they have absorbed the surface of a bubble promoting the formation of intermolecular protein-protein interactions; often occurring through hydrophobic and disulfide bonds.
Atsushi, Thermostability and aliphatic index of
globular proteins.
The 1962 Nobel Prize in chemistry went to John Kendrew and Max Perutz "for their studies of the structures of
globular proteins.
Their topics include what a polymer molecule looks like, polymers in nature, the physics of high elasticity,
globular proteins and folding, the dynamics of polymer fluids, and the mathematics of fractals as complicated polymer structures.
The molecular backbones of
globular proteins have an intricates structure.
We all know that whey protein is a mixture of
globular proteins isolated from whey, the liquid material created as a byproduct of cheese production.
