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a sulfonylurea used as a hypoglycemic in patients with type 2 diabetes mellitus whose blood glucose cannot be controlled by diet and exercise alone; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Glibenese (UK), Glucotrol, Glucotrol XL, Minodiab (UK)

Pharmacologic class: Sulfonylurea

Therapeutic class: Hypoglycemic

Pregnancy risk category C


Lowers blood glucose level by stimulating insulin release from pancreas, increasing insulin sensitivity at receptor sites, and decreasing hepatic glucose production. Also increases peripheral tissue sensitivity to insulin and causes mild diuresis.


Tablets: 5 mg, 10 mg

Tablets (extended-release): 5 mg, 10 mg

Indications and dosages

To control blood glucose in type 2 (non-insulin-dependent) diabetes mellitus in patients who have some pancreatic function and don't respond to diet therapy

Adults: 5 mg/day P.O. initially, increased as needed after several days (range is 2.5 to 40 mg/day). Give extended-release tablet once daily; maximum dosage is 20 mg/day. Give daily dosage above 15 mg in two divided doses.

Conversion from insulin therapy

Adults: With insulin dosage above 20 units/day, start with usual glipizide dosage and reduce insulin dosage by 50%. With insulin dosage of 20 units/day or less, insulin may be discontinued when glipizide therapy starts.

Dosage adjustment

• Hepatic or renal impairment

• Elderly patients


• Hypersensitivity to drug

• Severe renal, hepatic, thyroid, or other endocrine disease

• Uncontrolled infection, serious burns, or trauma

• Diabetic ketoacidosis

• Pregnancy or breastfeeding


Use cautiously in:

• mild to moderate hepatic, renal, or cardiovascular disease; impaired thyroid, pituitary, or adrenal function

• elderly patients.


• Check baseline creatinine level for normal renal function before giving first dose.

• Give daily dose (extended-release) at breakfast.

• Administer immediate-release tablets 30 minutes before a meal (preferably breakfast). If patient takes two daily doses, give second dose before dinner.

Adverse reactions

CNS: dizziness, drowsiness, headache, weakness

CV: increased CV mortality risk

EENT: blurred vision

GI: nausea, vomiting, diarrhea, constipation, cramps, heartburn, epigastric distress, anorexia

Hematologic: aplastic anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia

Hepatic: cholestatic jaundice, hepatitis

Metabolic: hyponatremia, hypoglycemia

Skin: rash, pruritus, erythema, urticaria, eczema, angioedema, photosensitivity

Other: increased appetite


Drug-drug. Androgens (such as testosterone), chloramphenicol, clofibrate, guanethidine, MAO inhibitors, nonsteroidal anti-inflammatory drugs (except diclofenac), salicylates, sulfonamides, tricyclic antidepressants: increased risk of hypoglycemia

Beta-adrenergic blockers: altered response to glipizide, requiring dosage change; prolonged hypoglycemia (with nonselective beta blockers)

Calcium channel blockers, corticosteroids, estrogens, hydantoins, hormonal contraceptives, isoniazid, nicotinic acid, phenothiazines, phenytoin, rifampin, sympathomimetics, thiazide diuretics, thyroid preparations: decreased hypoglycemic effect

Warfarin: initially increased, then decreased, effects of both drugs

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, cholesterol: increased values

Glucose, granulocytes, hemoglobin, platelets, white blood cells: decreased values

Drug-herbs. Aloe (oral), bitter melon, burdock, chromium, coenzyme Q10, dandelion, eucalyptus, fenugreek: additive hypoglycemic effects

Glucosamine: impaired glycemic control

Drug-behaviors. Alcohol use: disulfiram-like reaction

Patient monitoring

• Monitor blood glucose level, especially during periods of increased stress.

• Evaluate CBC and renal function tests.

• If patient is ill or has abnormal laboratory values, monitor electrolyte, ketone, glucose, pH, lactate dehydrogenase, and pyruvate levels.

• Monitor cardiovascular status.

Patient teaching

• Advise patient to take daily dose of extended-release tablets with breakfast or immediate-release tablet 30 minutes before breakfast (and second dose, if prescribed, before dinner).

• Advise patient to monitor blood glucose level as instructed by prescriber.

• Tell patient he may need supplemental insulin during times of stress or when he can't maintain adequate oral intake.

• Teach patient how to recognize signs and symptoms of hypoglycemia and hyperglycemia.

• Stress importance of diet and exercise to help control diabetes.

• Instruct patient to wear or carry medical identification describing his condition.

• Advise patient to keep sugar source at hand at all times in case of hypoglycemia.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient he'll undergo regular blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A sulfonylurea drug, C21H27N5O4S, used to treat type 2 diabetes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Glucotrol® Therapeutics A sulfonylurea used to control insulin in type 2 DM. See Diabetes mellitus.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A SULPHONYLUREA drug used to treat maturity onset (Type II) DIABETES. Brand names are Glibenese and Minodiab.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
A deliberately ingested her parent's glipizide and needs psychiatric admission
Schneider, Rapid extraction, identification and quantification of oral hypoglycaemic drugs (glipizide, glibenclamide, gliclazide, gliquidone and metformin) in serum and hair using LC- MS/MS, Forensic Sci.
Treatment was limited to supportive care and oral glipizide. Glipizide is a sulfonylurea drug that increases endogenous insulin secretion by interacting with sulfonylurea receptors or by inhibiting potassium channels on pancreatic beta cells.
[15] Amlodipine, Glipizide, Metformin, Prednisone, Propranolol, & Tacrolimus.
Mylan said the Glipizide Extended-release Tablets, 5 mg and 10 mg is generic version of Pfizer's GLUCOTROL XL.
And glibenclamide, gliquidone, glipizide and glimepiride are the common drugs in the class of sulfonylurea.
The other drugs are glimeperide gliclazide and glipizide which may be used in those who get frequent hypoglycaemic episodes with glibenclamide which is quite rare.
The most commonly prescribed two-drug combination was of metformin and glimepiride (9.3%) followed by metformin + voglibose (3.8%), metformin + pioglitazone (3.5%), metformin + glipizide (2.6%), metformin + insulin (1.6%), and metformin + glibenclamide (0.8%).
MEDICATION POTENTIAL INTERACTION Prescription diuretic (Lasix) Dehydration, electrolyte imbalance Lithium Increases side effects of lithium Blood-thinning medications Increased risk of bleeding (Coumadin, Plavix) Diabetes medications May reduce blood sugar levels (insulin, metformin, glipizide) too severely Antacids (i.e., Tums, Milk of Increases stomach acid and Magnesia) heartburn Ciproflaxin (Cipro, an Chinese dandelion lowers antibiotic) absorption Source:
The second generation sulfonylureas are more potent and include glimepiride, glipizide and glyburide.
The second-generation agents, glimepiride (Amaryl[R]), glipizide (Glucotrol[R] and Glucotrol XL[R]), and glyburide (Diabeta[R], Micronase[R], and Glynase[R]), have shorter half-lives and shorter onset of action than the first generation sulfonylureas such as chlorpropamide, (Diabinese[R]), tolazamide (Tolinase[R]), and tolbutamide (Orinase[R]).