The STELLUX[R] Chemi Glucagon ELISA is highly specific with 100% cross-reactivity to glucagon, and does not cross-react with other proglucagon peptides such as oxyntomodulin, glicentin
and the incretins glucagon-like peptide-1 and gastric inhibitory polypeptide.
Measures Glucagon (1-29) with no detectable cross-reactivity to Glicentin
, Oxyntomodulin, GLP-1, GLP-2, or GRPR Sensitive to 2.1 pg/mL (0.6 pmol/L).
, proglucagon, PYY, PP, and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells.
glicentin, oxyntomodulin, GLP-1 and GLP-2 derived from proglucagon
In humans, intestinal enteroendocrine L-cells synthesise glicentin
observations were not solely due to elevated glicentin and more likely
Thus, in addition to glucagon itself, proglucagon gives rise to several peptides containing the glucagon sequence, including oxyntomodulin, glicentin, and proglucagon 1-61, as well as molecules with some sequence homology to glucagon, including glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) and major proglucagon fragment .
This may reflect a specificity problem in assay C; for example, this assay could be cross-reacting with glucagon-like molecules (oxyntomodulin, glicentin, or glucagon-like peptide-1 [7, 11]) although not stated by the manufacturers.
Holst, "Evidence that glicentin contains the entire sequence of glucagon," The Biochemical Journal, vol.