glial fibrillary acidic protein


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Related to glial fibrillary acidic protein: Myelin basic protein

glial fibrillary acidic protein

[MIM*137780]
a cytoskeletal protein of 51 kD found in fibrillary astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.

GFAP

A gene on chromosome 17q21 that encodes a major class-III intermediate filament protein of mature astrocytes, which serves as a marker (in histopathology) to distinguish astrocytes from other glial cells, both during development and in tumour diagnostics.

Molecular pathology
Defects in GFAP are linked to Alexander disease.

gli·al fib·ril·la·ry a·cid·ic pro·tein

(glī'ăl fib'ri-lar-ē ă-sid'ik prō'tēn)
A cytoskeletal protein of 51 kD found in fibrous astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.

glial fibrillary acidic protein

Abbreviation: GFAP
An intermediate filament found only in astrocytes and astroglial cells. It forms part of the skeletal structure of neurons. Abnormalities in GFAP are found in a variety of neurological diseases, including Alzheimer's disease, Creutzfeldt-Jakob disease, and some brain tumors.
See also: protein
References in periodicals archive ?
Immunohistochemical localization of glial fibrillary acidic protein in human glial neoplasms.
Human glial fibrillary acidic protein gene promoter targets hepatic and pancreatic stellate cells in transgenic Bama mini-pigs.
Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke.
Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease.
Silverstein, "Hypoxic-ischemic brain injury stimulates glial fibrillary acidic protein mRNA and protein expression in neonatal rats," Experimental Neurology, vol.
Lamers, "Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein," Stroke, vol.
RA activates the promoter of GFAP, which encodes the astrocytic marker glial fibrillary acidic protein (GFAP), and is activated by a putative RA response element in the promoter.
As a marker of glial activity an antibody against the glial fibrillary acidic protein (anti-GFAP) was used , while the neuronal antinuclear antibody (Anti-NeuN) was used as a marker of neurodegeneration.
Cell culture was maintained until the 6th passage and during this period samples were collected for imunocytochemistry characterization using markers for glial fibrillary acidic protein (GFAP) (Dako Cytomation, Denmark), S100Protein (Dako Cytomation, Glostrup, Denmark) and vimentin (Dako Cytomation, Glostrup, Denmark).
BOSTON -- The biomarker glial fibrillary acidic protein accurately distinguished between mild and moderate traumatic brain injury between mild traumatic injury and controls, and between patients with and without intracranial lesions on CT in a prospective cohort study of emergency department patients with head injuries.
In recent times there has been several studies [12, 13] regarding the role of complex biochemical markers of brain damage: such as S100B protein, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), apolipoprotein E (ApoE), tumor necrosis factor (TNF)-[alpha], soluble tumor necrosis factor receptor I (sTNFR-I), and interleukins (IL) and markers of oxidative stress, such as malondialdehyde (MDA) in aSAH patients.
Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas.