glial cell line-derived neurotrophic factor


Also found in: Wikipedia.

glial cell line-derived neurotrophic factor (GDNF)

[glī′əl]
a nerve growth drug that has been used in laboratory animals to reverse the progression of symptoms of Parkinson's disease and other brain diseases. GDNF is believed to act as a biological shield, protecting nerve cells from damage that normally would destroy them.

GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
The corneal sensitivity, number of corneal nerve fibers, and contents of vascular endothelial growth factor (VEGF)-B and various neurotrophic factors such as nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in corneal tissue of four groups were observed.
We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.
The stem cells are specifically engineered to produce an important protein called, glial cell line-derived neurotrophic factor (GDNF).
The present study was conducted to evaluate the effect of SSC elimination on the gene expression of Glial cell line-Derived Neurotrophic Factor (GDNF), Fibroblast Growth Factor 2 (FGF2) and Kit Ligand (KITLG), which are the main growth factors regulating SSCs development and secreted by niche cells, primarily Sertoli cells.
A research team from Anhui University of Chinese Medicine in China conducted their study on rats to verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes and found that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor also increased in the ventral tegmental area following acupuncture.
These molecules include neurotrophic factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor [20,67-69].
Patients taking part in the latest study had the experimental drug glial cell line-derived neurotrophic factor (GDNF) pumped through a tiny catheter into the part of the brain damaged by the disease.
By adding a special protein substance that protects nerves called glial cell line-derived neurotrophic factor, the team discovered the stem cells can continuously proliferate in vitro.
Upregulation of glial cell line-derived neurotrophic factor (GDNF) in the rat cochlea following noise.