glial cell line-derived neurotrophic factor


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GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
The aim of this study was to investigate serum Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Nerve Growth Factor (NGF) levels in patients with tic disorder and healthy controls.
To induce MNPs into MNs, the rosettes were lifted with dispase (1 mg/ml) and then cultured in suspension in NDM with 0.5 [micro]M RA, 0.1 [micro]M Pur, 10ng/ml brain-derived neurotrophic factor (BDNF, PeproTech), 10ng/ml glial cell line-derived neurotrophic factor (GDNF, PeproTech), and 10ng/ml insulin-like growth factor (IGF, PeproTech) for 6 days.
Glial cell line-derived neurotrophic factor (GDNF) is a member of the neurotrophin family, and it is responsible for neuronal survival by protecting neurons from damage [13].
Safflower extract and aceglutamide injection promoting the expressions of the neurotrophic factors such as nerve growth factor and glial cell line-derived neurotrophic factor in the cornea of diabetic mice
(9) Retinal glial cells can produce several neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) that have neuroprotective effects under pathological conditions.
Estrogen and androgen actions involved in the morphological plasticity of pelvic neurons have been linked to the signaling of neurotrophic factors including ligands from the glial cell line-derived neurotrophic factor (GDNF) family (GFLs) [5, 11-17].
Tzeng, "Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury," Journal of Neuroscience Research, vol.
Studies have revealed that glial cell line-derived neurotrophic factor (GDNF) affects cognitive function, including learning and memory [35].
The stem cells are specifically engineered to produce an important protein called, glial cell line-derived neurotrophic factor (GDNF).
In this context, Glial cell line-Derived Neurotrophic Factor (GDNF), Fibroblast Growth Factor 2 (FGF2) and Kit Ligand (KITLG) are of the most important growth factors which have been identified to play pivotal role in regulation of SSCs development (2-4).
However, no reports have been simultaneously compared the neuroprotective and regenerative effects of several neurotrophic factors including neurotrophin-4 (NT-4), hepatocyte growth factor (HGF), glial cell line-derived neurotrophic factor (GDNF), and tauroursodeoxycholic acid (TUDCA) in AGE exposed retinas cultured in the same system.
A research team from Anhui University of Chinese Medicine in China conducted their study on rats to verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes and found that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor also increased in the ventral tegmental area following acupuncture.