KLK2

(redirected from glandular kallikrein 2)

KLK2

A gene on chromosome 19q13.33 that encodes a serine protease with diverse physiological functions, which may also have a role in carcinogenesis. KLK2 is highly expressed in prostate cancer and may serve as a prognostic marker for prostate cancer.
References in periodicals archive ?
Clinical value of human glandular kallikrein 2 and free and total prostate-specific antigen in serum from a population of men with prostate-specific antigen levels 3.0 ng/mL or greater.
Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker.
This article will discuss the biochemistry of PSA (human glandular kallikrein 3, or hK3) and its molecular forms, and human glandular kallikrein 2 (hK2), another member of the human kallikrein gene family.
Comparison of predictive accuracy for pathologically organ confined clinical stage T1c prostate cancer using human glandular kallikrein 2 and prostate specific antigen combined with clinical stage and Gleason grade.
Human glandular kallikrein 2 (hK2) is a serine protease very similar to PSA.
Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue.
hK3 [better known as prostate-specific antigen (PSA)] has been shown to form complexes with many extracellular protease inhibitors, such as [[alpha].sub.1]-antichymotrypsin, [[alpha].sub.2]-macroglobulin, and [[alpha].sub.1]-antitrypsin, and human glandular kallikrein 2 (hK2) was found to bind to [[alpha].sub.1]-antichymotrypsin, [[alpha].sub.2]-antiplasmin, antithrombin III, plasminogen activator inhibitor-1, and [[alpha].sub.2]-macroglobulin (12-20).
Determination and analysis of antigenic epitopes of prostate specific antigen (PSA) and human glandular kallikrein 2 (hK2) using synthetic peptides and computer modeling.
Human glandular kallikrein 2 (hK2) [6] is a prostatic secretory protein (1) expressing 80% identity in amino acid (2) sequence to prostate-specific antigen (PSA).
Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein 2. Clin Chem 1999;45:800-6.
The human kallikrein gene family was, until recently, thought to include only three members: KLK1, which encodes for pancreatic/renal kallikrein (hK1); [4] KLK2, which encodes for human glandular kallikrein 2 (hK2); and KLK3, which encodes for prostate-specific antigen (PSA; hK3) (3).