Like most other cancer grading systems, GL concentrates on the characteristics of the cancer cell and how it resembles the prostate glandular differentiation
. A low Gleason grade shows the greatest similarity to the glandular tissue of origin, while high Gleason grades show the greatest divergence from glandular forms.
Primary adenocarcinoma of the bladder is malignant tumor with histologically pure glandular differentiation
. It accounts for 0.5-2% of all primary bladder malignancies.
We observed that well-differentiated gastric and GE adenocarcinoma with prominent glandular differentiation
(Figure 1) largely expressed only basolateral HER2 IHC staining with no luminal staining (Figure 2).
No or only minimal glandular differentiation
from Al-Khobar have also reported adenocarcinoma being the most common GC (55 out of total 94 GC cases), unfortunately they have not further subtyped the adenocarcinoma.21 Moreover, we found a significant association between glandular differentiation
and patient's age.
Caption: Figure 1: High-magnification image showing a few glandular lumina with focal areas of loss of glandular differentiation
, a pattern consistent with Gleason grade 4 adenocarcinoma of the prostate (H & E, 400x)
Additionally, the tumor showed no glandular differentiation
, making metastatic pancreatic adenocarcinoma unlikely.
Nottinghams score was assessed in which the score for glandular differentiation
was 2(10-75% of tumor areas forming glandular /tubular structures), score for nuclear pleomorphism was 3(vesicular nuclei with prominent nucleoli exhibiting marked variation in size and shape), score for mitotic rate was 3(>8mitosis/10mm.
Immunohistochemistry was also performed, highlighting Carcinoembryonic Antigen (CEA) with elongated cells that line the cavities that support glandular differentiation
. S100 staining was observed in the dendritic cells and melanocytes in the thickness of the cell proliferation (Fig.
There was no evidence of squamous or glandular differentiation
. There was no dysplasia within the adjacent squamous epithelium.
Subbuswamy et al.1 As the nomenclature implies, these tumors possess morphological features suggestive of both carcinoid and glandular differentiation
. Reports from the medical literature on goblet cell carcinoid are sparse; however, the general consensus is that the clinical behaviour of goblet cell carcinoid is intermediate between carcinoid and adenocarcinoma.5,6 It is a more aggressive neoplasm compared with appendiceal carcinoid but is more indolent compared with adenocarcinoma.7 Most tumors are confined to the appendix at the time of diagnosis and the prognosis is good.8
is an infrequent variant of urothelial cancer, with an incidence of up to 16%.[sup.7] Patients with only glandular differentiation
should be labelled as adenocarcinoma, rather than urothelial cancer with glandular differentiation