gingival fibromatosis 1
gingival fibromatosis 1A rare autosomal dominant condition (OMIM:135300) characterised by a benign, slowly progressive, nonhaemorrhagic, fibrous enlargement of maxillary and mandibular keratinised gingivae.
Caused by defects of SOS1, which encodes a guanine nucleotide exchange factor for RAS proteins, a family of membrane proteins that bind guanine nucleotides and participate in signal transduction pathways.
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