works in many ways for the protection of underlying connective tissue.
Analysis of proliferative activity in oral gingival epithelium
in immunosuppressive medication induced gingival overgrowth.
The gingival epithelium
as well as connective tissue have a very high turnover rate and new cells are constantly produced to replace cells, which are lost through cell death or migration.
The presence of the bacteria induces the production of cytokines and chemokines by the gingival epithelium
. This results in the expression of adhesion molecules, increased permeability of gingival capillaries and chemotaxis of polymorphonuclear neutrophils through the junctional epithelium and into the gingival sulcus.
Nearly no immunostaining could be found in the healthy gingival epithelium
Methodology: Aqueous extract of areca nut, and Phosphate Buffered Saline (as control) was applied to the surface of the buccal epithelium and gingival epithelium
. The morphology of the stratified oral epithelial model was examined at 24 and 48 hours by using formalin fixed paraffin embedded tissue.
In GTR procedure use of barriers exclude gingival epithelium
and connective tissue from the root surface, which hinders regeneration, stabilize blood clot, maintain space where regenerative tissues may form and allow time for new connective tissue attachment to become established on root surface.
(2) Drug induced gingival overgrowth may be due to hyperplasia of gingival epithelium
or of submucosal connective tissue or of both, the major drugs that causes gingival hyperplasia are phenytoin (anti-convulsant), cyclosporine (immunosuppressant) and nifedipine and amlodipine (calcium channel blockers).