giant cell tumor of bone


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gi·ant cell tu·mor of bone

a soft, reddish-brown, sometimes malignant, osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells, occurring most frequently in an end of a long tubular bone of young adults.

giant cell tumor of bone

giant cell tumor of bone

A lesion that comprises 5% of all osseous tumors, which is most common in the weight-bearing epiphysis of ♀ > age 20, which affects the distal femur, proximal tibia, distal radius; 60% recur with curettage; 10% metastasize, an event far more common in deep–to the fascial planes–tumors DiffDx A GCT-like histopathologic lesion may be seen in the brown tumor of hyperparathyroidism, chondroblastoma, giant cell reparative granuloma, benign and malignant fibrous histiocytoma, nonossifying and chondromyxoid fibroma, unicameral bone cyst, aneurysmal bone cyst, fibrous dysplasia, osteoblastoma, osteosarcoma, osteoid osteoma, eosinophilic granuloma.

gi·ant cell tu·mor of bone

(jī'ănt sel tū'mŏr bōn)
A soft, reddish-brown, sometimes malignant, osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells, occurring most frequently in an end of a long tubular bone of young adults.
Synonym(s): giant cell myeloma, osteoclastoma.

gi·ant cell tu·mor of bone

(jī'ănt sel tū'mŏr bōn)
A soft, reddish-brown, sometimes malignant, osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells; most frequent in young adults.
Synonym(s): osteoclastoma.
References in periodicals archive ?
Giant cell tumor of bone is a locally aggressive, benign tumor afflicting younger adults between the ages 20 to 40.
25) Specifically, both the JST and the MC patients share the same age distribution pattern with regard to giant cell tumor of bone and Ewing sarcoma.
In particular, both the JST and the MC patients show the similar skeletal site distribution pattern for giant cell tumor of bone and Ewing sarcoma.
Distribution of giant cell tumor of bone by age in the Chinese and US groups.
The differential diagnosis for GCRG includes other giant cell-rich lesions, such as giant cell tumor of bone and low-grade intramedullary osteosarcoma.
Moreover, giant cell tumor of bone affects the epiphyseal ends of the skeletally mature patient, as opposed to NOF, which never affects the epiphysis.
The sensitivity, specificity, positive predictive value, and negative predictive value of p63 immunohistochemistry for the diagnosis of giant cell tumor of bone were 86.
This study failed to reproduce the results of 2 previous studies portraying p63 as a potential diagnostic marker of giant cell tumor of bone.
The results of various types of treatment of giant cell tumor of bone are not uniformly successful.
Immunohistochemical study of mononuclear phagocyte antigens in giant cell tumor of bone.