giant cell hepatitis

ne·o·na·tal hep·a·ti·tis

hepatitis in the neonatal period presumed to be due to any of a variety of causes, chiefly viral; characterized by direct and indirect bilirubinemia, hepatocellular degeneration, and appearance of multinucleated giant cells; may be difficult to distinguish from biliary atresia, but is more likely to end with recovery, although cirrhosis may develop.
A nonspecific reaction of the newborn liver to increased conjugated hyperbilirubinemia, which occurs with intra- or extrahepatic biliary atresia, erythroblastosis fetalis, TORCH (toxoplasmosis, rubella, cytomegalovirus, herpes simplex) and other in utero and neonatal infections (e.g., coxsackie, hepatitis, Escherichia coli infection, syphilis) and metabolic defects (e.g., a1-antitrypsin deficiency; cystic fibrosis; hereditary fructose intolerance; galactosemia; tyrosinosis requiring parenteral nutrition; choledocal cysts, idiopathic, congenital hepatic fibrosis, trisomy 18 and Byler’s, Lucey-Driscoll, Niemann-Pick and Zellweger’s diseases)

giant cell hepatitis

Giant cell transformation of liver Neonatology A nonspecific reaction of the newborn liver to ↑ conjugated hyperbilirubinemia; conjugated BR is ↑ in infants with intra- or extrahepatic biliary atresia, erythroblastosis fetalis, TORCH–toxoplasmosis, rubella, CMV, HS, and other in utero and neonatal infections–eg, coxsackie, hepatitis, E coli, syphilis, metabolic defects–eg, α1-antitrypsin deficiency, cystic fibrosis, hereditary fructose intolerance, galactosemia, parenteral nutrition and tyrosinosis, choledocal cysts, idiopathic, congenital hepatic fibrosis, Byler's disease, Lucy-Driscoll disease, Niemann-Pick disease, trisomy 18, and Zellweger's disease. Cf Syncytial giant cell hepatitis.
References in periodicals archive ?
Syncytial giant cell hepatitis (GCH) is a condition characterized by inflammation and multinucleated hepatocytes, commonly found in wide spectrum of neonatal and infantile liver diseases [1].
Westerhoff et al., "Neonatal giant cell hepatitis: Histological and etiological findings," The American Journal of Surgical Pathology, vol.
Giant cell hepatitis with autoimmune hemolytic anemia in children: Proposal for therapeutic approach.
[sup][3] Liver biopsy often shows giant cell hepatitis, and at late stages, bridging fibrosis and micronodular cirrhosis can also be seen.
A wide spectrum of primary liver diseases in systemic lupus erythematosus have been demonstrated by various authors and include viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, granulomatous hepatitis, giant cell hepatitis, chronic hepatitis with IgA or IgD deficiency, porphyria or idiopathic portal hypertension, and rarely lymphoma.
McMahon, "Giant cell hepatitis associated with systemic lupus erythematosus," Journal of Clinical Pathology, vol.
Giant cell hepatitis associated with direct Coombs' test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear.
Key words: Giant cell hepatitis, immune hemolytic anemia, direct Coombs' test, rituximab
Liver histology showed, among other features, a giant cell hepatitis which has not yet been described for drug-induced liver disease (Zimmerman, 1999).
This leaves a large group of infants with what is called IDIOPATHIC NEONATAL HEPATITIS, Giant Cell Hepatitis or familial Cholestatis.
Giant cell hepatitis, however, is usually caused by various degrees of insults to the immature liver, or can be idiopathic.

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