giant cell granuloma

gi·ant cell gran·u·lo·ma

a nonneoplastic lesion characterized by a proliferation of granulation tissue containing numerous multinucleated giant cells; it occurs in the gingiva and alveolar mucosa (occasionally in other soft tissues) where it presents as a soft red-blue hemorrhagic nodular swelling; it also occurs within the mandible or maxilla as a unilocular or multilocular radiolucency; microscopically similar lesions occur in the tubular bones of the hands and feet, are considered neoplastic and may have a malignant course. Identical bony lesions may be seen in hyperparathyroidism and cherubism.
See also: giant cell tumor of bone.
(1) Central giant cell granuloma
(2) Peripheral giant cell granuloma

gi·ant cell gran·u·lo·ma

(jī'ănt sel gran'yū-lō'mă)
A nonneoplastic lesion characterized by a proliferation of granulation tissue containing numerous multinucleated giant cells; it occurs on the gingiva and alveolar mucosa (occasionally on other soft tissues) where it presents as a soft red-blue hemorrhagic nodular swelling; it also occurs within the mandible or maxilla as a unilocular or multilocular radiolucency. Identical bony lesions may be seen in hyperparathyroidism and cherubism.
See also: giant cell tumor of bone
Compare: giant cell fibroma

gi·ant cell gran·u·lo·ma

(jī'ănt sel gran'yū-lō'mă)
Nonneoplastic lesion characterized by a proliferation of granulation tissue containing numerous multinucleated giant cells; occurs in gingiva and alveolar mucosa (occasionally in other soft tissues) where it presents as a soft red-blue hemorrhagic nodular swelling; also occurs within the mandible or maxilla as a unilocular or multilocular radiolucency.
References in periodicals archive ?
Aggressive central giant cell granuloma of the mandible, a diagnostic dilemma.
Histopathologically, giant cell diagnosis can be inaccurately identified with giant cell granuloma, aneurysmal bone cyst, brown tumor of hyperparathyroidism, fibrous dysplasia, cherubism, and chondroblastoma [1].
The initial biopsy was read as "central giant cell granuloma." Conservative management yielded no improvement, and the tumor grew steadily.
Based on the clinical and radiographic examination, a provisional diagnosis of keratocystic odontogenic tumor was given with the differential diagnoses of ameloblastoma, aneurysmal bone cyst, central giant cell granuloma, and central hemangioma owing to the multilocular radiolucent pattern of the present lesion.
Thus, based on the client's medical history and clinical examination, a differential diagnosis of pregnancy tumour (granuloma gravidarum), peripheral giant cell granuloma, and peripheral ossifying fibroma was made.
Since the lesion presented as a firm painless well-circumscribed swelling in the anterior gingiva and additionally the patient had a fair Silness and Loe plaque index, reactive lesions due to chronic low-grade irritation (dental plaque and food impaction) like peripheral ossifying fibroma, healing pyogenic granuloma, peripheral giant cell granuloma, and giant cell fibroma were considered as differential diagnoses.
Recently, it was reported that a giant cell granuloma grew around polypropylene suture that had been used in a tendon transfer procedure, and the histopathology was consistent with a foreign-body reaction to the polypropylene material.
In this context, the potential diagnoses included pyogenic granuloma, focal fibrous hyperplasia, peripheral giant cell granuloma, and peripheral ossifying fibroma.
This provides differentiation from additional entities that typically include giant cells: cherubism, central giant cell granuloma, giant cell tumor in the setting of paget's disease, and aneurysmal bone cyst.
Differential diagnosis includes peripheral odontogenic fibroma, pyogenic granuloma, peripheral giant cell granuloma, peripheral ameloblastoma, and calcifying epithelial odontogenic tumor.
An Indian study has reported 7 ectopic parathyroid adenomas out of 51 cases operated for PHPT.24 One patient with jaw mass had a giant cell granuloma, which is rarely seen as a sole manifestation of PHPT.

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