giant cell arteritis


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arteritis

 [ahr″ter-i´tis] (pl. arteri´tides)
inflammation of an artery.
aortic arch arteritis pulseless disease.
brachiocephalic arteritis pulseless disease.
cranial arteritis temporal arteritis.
giant cell arteritis temporal arteritis.
hemolytic arteritis, microangiopathic pulseless disease.
arteritis obli´terans endarteritis obliterans.
rheumatic arteritis generalized inflammation of arterioles and arterial capillaries occurring in rheumatic fever.
Takayasu's arteritis pulseless disease.
temporal arteritis a chronic vascular disease of unknown origin, occurring in the elderly, characterized by severe headache, fever, and accumulation of giant cells in the walls of medium-sized arteries, especially the temporal arteries. Ocular involvement may cause visual impairment or blindness.

tem·po·ral ar·te·ri·tis

[MIM*187360]
a subacute, granulomatous arteritis involving the external carotid arteries, especially the temporal artery; occurs in old people and may be manifested by constitutional symptoms, particularly severe headache, and sometimes sudden unilateral blindness. Erythrocyte sedimentation rate is always elevated. Shares many of the symptoms of polymyalgia rheumatica.
A condition that affects people > age 50, incidence 18:100,000/yr, characterised by arterial vasculitis; it can lead to blindness and/or stroke
Diagnosis Arterial biopsy
Management High dose corticosteroids

giant cell arteritis

Cranial arteritis, Horton's disease, temporal arteritis Neurology A condition that affects > age 50, incidence 18:100,000/yr, characterized by arterial vasculitis; it can lead to blindness and/or stroke Clinical New-onset headache, scalp tenderness, jaw claudication, polymyalgia rheumatica Diagnosis Arterial Bx Management High dose corticosteroids. See Vasculitis.

tem·po·ral ar·ter·i·tis

(tem'pŏr-ăl ahr'tĕr-ī'tis)
A subacute, granulomatous arteritis involving the external carotid arteries, especially the temporal artery; occurs in elderly people and may be manifested by constitutional symptoms, particularly severe headache, and sometimes sudden unilateral blindness. Shares many of the symptoms of polymyalgia rheumatica.
Synonym(s): cranial arteritis, giant cell arteritis, Horton arteritis.

giant cell arteritis

See TEMPORAL ARTERITIS.

Giant cell arteritis

Also called temporal arteritis. A condition which causes the inflammation of temporal arteries. It can cause blindness when the inflammation effects the ophthalmic artery.

arteritis, temporal 

An inflammatory disease of the wall of arteries, mainly of the extracranial vessels, which occurs in people who are over 60 years of age. The condition is characterized by headache and pain in muscles and joints, such as those of the jaws, tender or non-pulsating temporal artery, and sometimes fever. A sudden loss of vision in one eye (amaurosis fugax) may occur in the first few weeks after the onset of the disease due to an occlusion of either the central retinal artery or of the short posterior ciliary arteries that supply the optic nerve. Prompt administration of systemic corticosteroids (e.g. hydrocortisone) has been found to be of great value in the management of this condition. Syn. giant cell arteritis (strictly speaking this term is usually reserved for a more generalized condition). See amaurosis fugax; ischaemic optic neuropathy; Adie's pupil.
References in periodicals archive ?
Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum 1993;36:1286-94.
Influence of traditional risk factors of atherosclerosis in the development of severe ischemic complications in giant cell arteritis. Medicine 2004;83:342-7.
For Sjogren's syndrome, lupus, giant cell arteritis, and scleroderma, study results are mixed or limited
(2.) Nuenninghoff DM, Matteson EL.The role of disease-modifying antirheumatic drugs in the treatment of giant cell arteritis. Clin Exp Rheumatol.
* Sudden, unilateral, painless--Central retinal vein/artery occlusion, giant cell arteritis, retinal detatchment and wet AMD
Rheumatic signs and manifestations of infective endocarditis were reported in some series of cases.[1-3] Infective endocarditis is reported to have a wide range of musculoskeletal symptoms varying from myalgia to PMR.[1-3] But mimicking of PMR by infective endocarditis is a very rare condition; for instance, it was reported as one in 110 patients in a series of studies published by Gonzolez-Juanatey et al.[3] In a nationwide French study of giant cell arteritis conducted on 400 patients, a case of initially misdiagnosed infective endocarditis is mentioned.[8] In a literature scan through the Medline search motor, we could find only a few case reports related to this topic.[3,9-12]
However, in a randomized, placebo-control study of 40 polymyalgia rheumatica patients, 6 with giant cell arteritis, the addition of methotrexate to corticosteroid treatment made no difference in time to remission, duration of remission, number of relapses, or cumulative dose of prednisone (Ann.
Polymyalgia rheumatica; giant cell arteritis; prednisone.
M2 PHARMA-May 23, 2017-US FDA approves first drug Actemra for treating giant cell arteritis
American College of Rheumatology : "Giant Cell Arteritis"
The most important therapeutic intervention is where the CRAO is associated with giant cell arteritis (GCA) and high dose systemic steroids must be administered before the fellow eye is affected.